2-(Chloromethyl)furan

Base Information

• Chemical Name: 2-(Chloromethyl)furan
• CAS No.: 617-88-9
• Molecular Formula: C5H5 Cl O
• Molecular Weight: 116.547
• Hs Code.: 2932190090
• NSC Number: 929
• DSSTox Substance ID: DTXSID60277135
• Nikkaji Number: J603.773I
• Wikidata: Q72454049
• Mol file: 617-88-9.mol

Synonyms:2-(CHLOROMETHYL)FURAN;2-chloromethylfuran;617-88-9;FURFURYL CHLORIDE;Furan, 2-(chloromethyl)-;NSC929;2-CHLOROMETHYL-FURAN;SCHEMBL281641;DTXSID60277135;NSC-929;AMY26896;MFCD08704320;STL282775;AKOS000262184;MB06568;FT-0768899;A901157

Chemical Property of 2-(Chloromethyl)furan

Chemical Property:

• Vapor Pressure: 8.18mmHg at 25°C
• Refractive Index: 1.478
• Boiling Point: 138.9 °C at 760 mmHg
• Flash Point: 37.8 °C
• PSA: 13.14000
• Density: 1.166 g/cm³
• LogP: 2.01840
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 116.0028925
• Heavy Atom Count: 7
• Complexity: 56

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloromethylfuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)CCl

Technology Process of 2-(Chloromethyl)furan

There total 14 articles about 2-(Chloromethyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) → 2-Chloromethylfuran (617-88-9)

Guidance literature:

With 1,2,3-Benzotriazole; thionyl chloride; In dichloromethane; at 20 ℃;

DOI:10.1055/s-1999-2943

Reference yield: 60.0%

1-Chloro-penta-3,4-dien-2-one (20207-56-1) → 2-Chloromethylfuran (617-88-9) + (E)-1-Chloro-4-(5-chloromethyl-furan-3-yl)-pent-3-en-2-one

Guidance literature:

tetrakis(2,2,2-trifluoroethoxycarbonyl)palladacyclopentadiene; In acetone; Ambient temperature;

Reference yield: 43.0%

Furfenorex (3776-93-0,13445-60-8) + acetyl chloride (75-36-5) → 2-Chloromethylfuran (617-88-9) + N-acetylmethamphetamine (27765-80-6)

Guidance literature:

In diethyl ether;

upstream raw materials:

(2-furyl)methyl alcohol

methanesulfonic acid furan-2-ylmethyl ester

1-Chloro-penta-3,4-dien-2-one

Furfenorex

Downstream raw materials:

2,2-[oxybis(methylene)]bis-furan

1-phenyl-3-(2-furyl)prop-1-yne

2-(methoxymethyl)furan

2,5-bis-chloromethyl-furan

Refernces

• 1、 -. "Application of 1-substituted-1H-imidazole-2-carboxylic acid compounds in preparation of metal beta-lactamase inhibitors". Paragraph 0180-0182. . Retrieved 2020/06/09.
• 2、 -. "Full-biological vegetable oil polyhydric alcohol and preparation method and application thereof". Paragraph 0059-0061; 0064-0066; 0069-0071; 0074-0076. . Retrieved 2019/01/15.