Synonyms:COPPER CHLORIDE;COPPER ATOMIC SPECTROSCOPY STANDARD;COPPER AA STANDARD CONCENTRATE;Copper, diaquadichloro-;HAMP-OL;Copper (II) chloride, 9.5% min in graphite;Cupric Chloride, Dihydrate, Crystal, Reagent
98% *data from raw suppliers
Copper (II) chloride, 99.999% 99.999% *data from reagent suppliers
The research focuses on the development of an efficient PdII/Pd0-p-benzoquinone/hydroquinone-CuCl2/CuCl catalytic system that utilizes molecular oxygen as the terminal oxidant to catalyze the cyclization-carbonylation-cyclization coupling reaction (CCC-coupling reaction) of (o-alkynyl phenyl) (methoxymethyl) sulfides. The purpose of this study was to create a more environmentally friendly and efficient method for synthesizing bis(benzothiophen-3-yl) methanones, which are important structural motifs found in various drugs and biologically active compounds. The researchers successfully optimized the reaction conditions and demonstrated that the system could tolerate a variety of substrates, including those with electron-donating, electron-withdrawing groups, and different halogen substituents. The synthesized compounds 2p and 2l showed androgen receptor (AR) agonistic activity, suggesting that the dibenzo[b]thiophenyl ketone scaffold could be a potential pharmacophore for non-steroidal AR-agonists. Key chemicals used in the process include p-benzoquinone, CuCl2, methanol, and carbon monoxide, along with the palladium catalyst [Pd(tfa)2(L2)].
The study concluded that conformational restrictions imposed by unsaturation in the connecting chain do not adversely affect the Class III activity of these compounds, suggesting that a folded conformation of the molecule is not required for Class III activity. The research also indicated that a certain degree of lipophilicity is needed for large ammonium species to cross intestinal membranes, and that the new compounds exhibit comparably low gastrointestinal bioavailability as observed for clofilium. Key chemicals used in the process include various substituted anilines, butadienes, copper(II) chloride, calcium oxide, and different tertiary amines, among others.
The study focuses on the synthesis, characterization, and structural analysis of copper(II)-thiosulfate complexes with tripodal tetraamine ligands, specifically tren, Bz3tren, Me6tren, and Me3tren. The reaction of [Cu(L)(H2O)]2+ with thiosulfate in aqueous solution results in a color change indicative of thiosulfate coordination to Cu(II). The research explores the formation of complexes, their stability, and the impact of different ligands on the oxidation of thiosulfate. Single-crystal X-ray diffraction analyses were conducted on three thiosulfate complexes, revealing a trigonal bipyramidal geometry around the copper(II) center. The study also includes the determination of thiosulfate binding constants for each Cu(II)-amine complex, with the aim of finding alternatives to the traditional cyanidation process in gold processing. The results show that the complexes with Bz3tren and Me3tren exhibit the highest thiosulfate binding constants reported to date, while the complex with Me6tren is less stable and more prone to oxidize thiosulfate. This research contributes to the development of more environmentally friendly and efficient gold-processing methods.
The research focuses on the development of bifunctional stilbene derivatives, L1-a and L1-b, designed to target and modulate metal-amyloid-β (Aβ) species, which are implicated in the pathogenesis of Alzheimer's disease (AD). The study involves a rational structure-based design approach that incorporates a metal binding site into the structure of an Aβ interacting molecule. The experiments conducted include UV-vis spectroscopy, X-ray crystallography, high-resolution 2D NMR, and docking studies to explore the reactivity of these compounds towards metal-Aβ species. The analyses used assess the compounds' ability to modulate metal-induced Aβ aggregation, neurotoxicity, and ROS (reactive oxygen species) production in vitro and in living cells. The reactants include Aβ peptides, metal chloride salts (CuCl2 or ZnCl2), and the synthesized bifunctional compounds L1-a and L1-b. The research provides insights into the structure-interaction-reactivity relationship, which is essential for designing small molecules to target metal-Aβ species and modulate their associated neurotoxicity and aggregation pathways.
The research focuses on the reactions of 1,4-bisphosphonium salts, which contain a common buta-1,3-dienylene group, with halogenating agents such as halogens and copper halides. The study aimed to investigate the expected 1,2- or 1,4-addition products; however, it was found that instead, adducts with complex anions were formed quantitatively. The experiments involved the use of various reagents, including bromine, copper(II) bromide, and copper(II) chloride, to react with the phosphonium salts. Analytical techniques employed included 1H and 31P NMR spectroscopy, UV spectroscopy, and X-ray diffraction analysis to characterize the products and confirm the structures of the complexes formed. Elemental analysis was also performed to determine the composition of the reaction products. The research revealed that the positive charge on phosphorus in the complexes was compensated by complex anions such as [Cu2Br6]2–, and the study also touched upon the potential bactericide activity and toxicity of the synthesized compounds.
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