Methylbis(hydroxymethyl)phosphine

Base Information

• Chemical Name: Methylbis(hydroxymethyl)phosphine
• CAS No.: 5958-52-1
• Molecular Formula: C3H9O2P
• Molecular Weight: 108.0761
• NSC Number: 138559
• DSSTox Substance ID: DTXSID00974979
• Wikidata: Q82959463
• Mol file: 5958-52-1.mol

Synonyms:Methylbis(hydroxymethyl)phosphine;5958-52-1;NSC138559;(Methylphosphanediyl)dimethanol;SCHEMBL5002459;DTXSID00974979;AKOS006280820;NSC-138559

Chemical Property of Methylbis(hydroxymethyl)phosphine

Chemical Property:

• Vapor Pressure: 0.0265mmHg at 25°C
• Boiling Point: 218.6°Cat760mmHg
• Flash Point: 86°C
• Density: g/cm³
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 108.03401652
• Heavy Atom Count: 6
• Complexity: 28

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CP(CO)CO

Technology Process of Methylbis(hydroxymethyl)phosphine

There total 3 articles about Methylbis(hydroxymethyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

tetrakis(hydroxymethyl)phosphonium chloride (124-64-1) + methyl iodide (74-88-4) → [hydroxymethyl(methyl)phosphanyl]methanol (5958-52-1)

Guidance literature:

tetrakis(hydroxymethyl)phosphonium chloride; With triethylamine; at 20 ℃; for 18h;

methyl iodide; In tetrahydrofuran; at -40 - 20 ℃;

Reference yield:

Tris-(hydroxymethyl)-methylphosphoniumhydroxid → [hydroxymethyl(methyl)phosphanyl]methanol (5958-52-1)

Guidance literature:

With triethylamine; at 20 ℃; neat (no solvent);

DOI:10.1021/om201168h

Reference yield:

→ [hydroxymethyl(methyl)phosphanyl]methanol (5958-52-1)

Guidance literature:

upstream raw materials:

tetrakis(hydroxymethyl)phosphonium chloride

methyl iodide

Downstream raw materials:

C₁₅H₁₉N₂P

3,7-Dimethyl-1,5-diphenyl-[1,5,3,7]diazadiphosphocane

3-Methyl-1,5-bis-(1-phenyl-ethyl)-[1,5,3]diazaphosphepane

C₁₇H₁₇Cl₂N₂O₄P

Refernces

• 1、 Doud, Michael D.,Grice, Kyle A.,Lilio, Alyssia M.,Seu, Candace S.,Kubiak, Clifford P.. "Versatile synthesis of PR2NR′ 2 ligands for molecular electrocatalysts with pendant bases in the second coordination sphere". scheme or table. p. 779 - 782. Retrieved 2012/05/04.