4-Pyrrolidin-2-ylpyridine

Base Information

Chemical Name:4-Pyrrolidin-2-ylpyridine
CAS No.:128562-25-4
Molecular Formula:C₉H₁₂N₂
Molecular Weight:148.208
Hs Code.:2933399990
European Community (EC) Number:696-435-4
DSSTox Substance ID:DTXSID50378004,DTXSID901305418
Nikkaji Number:J1.712.397A
Mol file:128562-25-4.mol

Synonyms:4-pyrrolidin-2-ylpyridine;128562-25-4;4-(2-pyrrolidinyl)pyridine;4-(pyrrolidin-2-yl)pyridine;4-Pyrrolidin-2-Yl-Pyridine;2-(4-Pyridyl)pyrrolidine;130343-15-6;PYRIDINE, 4-(2-PYRROLIDINYL)-;Pyridine, 4-(2-pyrrolidinyl)-, (+)- (9CI);Pyridine, 4-(2-pyrrolidinyl)-, (-)- (9CI);130343-14-5;MFCD01862536;4-((2S)PYRROLIDIN-2-YL)PYRIDINE;(R)-4-Pyrrolidin-2-yl-pyridine;(S)-4-Pyrrolidin-2-yl-pyridine;1197239-21-6;(+/-)-4-(Pyrrolidin-2-yl)pyridine;SCHEMBL168915;AMY5558;DTXSID50378004;GDGNPIOGJLCICG-UHFFFAOYSA-N;(-)-4-(2-Pyrrolidinyl)pyridine;4-(2-Pyrrolidinyl)pyridine,96%;DTXSID901305418;rac.-2-(pyridin-4-yl)pyrrolidine;(RS)-4-(2-pyrrolidinyl)-pyridine;AR1070;BBL020548;STK893237;AKOS001378684;AKOS016343657;4-pyrrolidin-2-ylpyridine, AldrichCPR;AB49753;AB49756;CS-W002850;PS-3581;SB32686;SB32687;AC-24298;SY005586;BB 0249475;FT-0643093;FT-0694674;EN300-27335;A26474;W-205324;4-(2-Pyrrolidinyl)pyridine;Z238920298;66269-97-4

Suppliers and Price of 4-Pyrrolidin-2-ylpyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(2-Pyrrolidinyl)pyridine
1g
$ 1055.00

SynQuest Laboratories
4-(Pyrrolidin-2-yl)pyridine
250 mg
$ 37.00

SynQuest Laboratories
4-(Pyrrolidin-2-yl)pyridine
1 g
$ 320.00

Labseeker
4-(2-Pyrrolidinyl)pyridine 95
1g
$ 417.00

J&W Pharmlab
4-Pyrrolidin-2-yl-pyridine 97%
25g
$ 1390.00

J&W Pharmlab
4-Pyrrolidin-2-yl-pyridine 97%
5g
$ 398.00

Crysdot
4-Pyrrolidin-2-ylpyridine 95+%
5g
$ 346.00

Chemenu
4-(pyrrolidin-2-yl)pyridine 95%
25g
$ 1103.00

Chemenu
4-(pyrrolidin-2-yl)pyridine 95%
10g
$ 542.00

Chemenu
4-(pyrrolidin-2-yl)pyridine 95%
5g
$ 337.00

Total 48 raw suppliers

Chemical Property of 4-Pyrrolidin-2-ylpyridine

Chemical Property:

Vapor Pressure:0.0179mmHg at 25°C
Boiling Point:253.81 °C at 760 mmHg
PKA:8.84±0.10(Predicted)
Flash Point:107.301 °C
PSA：24.92000
Density:1.043 g/cm³
LogP:1.83490
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Water Solubility.:Slightly soluble in water.
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:148.100048391
Heavy Atom Count:11
Complexity:119

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Pyrrolidinyl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)C2=CC=NC=C2
Uses 4-Pyrrolidin-2-ylpyridine can be used in aldol catatlysis, in the preparation of azole compounds as 11β-HSD1 inhibitors as well as in the asymetric synthesis of pyrazolodihydropyrimidinylpyrrolidin amide derivatives. 4-(2-Pyrrolidinyl)-pyridine can be used in aldol catatlysis, in the preparation of azole compounds as 11β-HSD1 inhibitors as well as in the asymetric synthesis of pyrazolodihydropyrimidinylpyrrolidin amide derivatives.

Technology Process of 4-Pyrrolidin-2-ylpyridine

There total 4 articles about 4-Pyrrolidin-2-ylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₁₃H₁₇N₃

: 66269-75-8,128562-25-4,130343-14-5,130343-15-6
4-(pyrrolidin-2-yl)pyridine

Guidance literature:: With trifluoroacetic acid; hydrazine; In ethanol; at 120 ℃; for 1h;
DOI:10.1021/ja072577n

Reference yield:

: 66269-78-1
4-(3,4-dihydro-2H-pyrrol-5-yl)pyridine

: 66269-75-8,128562-25-4,130343-14-5,130343-15-6
4-(pyrrolidin-2-yl)pyridine

Guidance literature:: With sodium tetrahydroborate; acetic acid; In methanol;
DOI:10.1021/ja017774f

Reference yield:

: 1570-45-2
isonicotinic acid ethylester

: 66269-75-8,128562-25-4,130343-14-5,130343-15-6
4-(pyrrolidin-2-yl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran

1.2: HCl

1.3: NaOH

2.1: NaBH₄; AcOH / methanol

With sodium tetrahydroborate; sodium hydride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/ja017774f