5,6-Dihydro-2H-pyran-3-methanol

Base Information

• Chemical Name: 5,6-Dihydro-2H-pyran-3-methanol
• CAS No.: 14774-35-7
• Molecular Formula: C6H10 O2
• Molecular Weight: 114.144
• Hs Code.: 2932999099
• European Community (EC) Number: 238-840-7
• UNII: JZK3VJ5JRY
• DSSTox Substance ID: DTXSID50163795
• Nikkaji Number: J227.183D
• Wikidata: Q83032787
• Mol file: 14774-35-7.mol

Synonyms:14774-35-7;5,6-Dihydro-2H-pyran-3-methanol;(5,6-Dihydro-2H-pyran-3-yl)methanol;2h-pyran-3-methanol, 5,6-dihydro-;3,6-dihydro-2H-pyran-5-ylmethanol;(5,6-Dihydro-2H-pyran-3-yl)-methanol;JZK3VJ5JRY;EINECS 238-840-7;UNII-JZK3VJ5JRY;SCHEMBL10721188;DTXSID50163795;AKOS006305128;AT26645;SB33737;5,6-DIHYDRO-2H-PYRAN-3-YLMETHANOL;CS-0250417;FT-0703462;EN300-5074650

Chemical Property of 5,6-Dihydro-2H-pyran-3-methanol

Chemical Property:

• Vapor Pressure: 0.0423mmHg at 25°C
• Boiling Point: 211°Cat760mmHg
• Flash Point: 94.5°C
• PSA: 29.46000
• Density: 1.063g/cm³
• LogP: 0.32540
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 114.068079557
• Heavy Atom Count: 8
• Complexity: 96.7

Purity/Quality:

97% ^*data from raw suppliers

(5,6-Dihydro-2H-pyran-3-yl)-methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCC(=C1)CO

Technology Process of 5,6-Dihydro-2H-pyran-3-methanol

There total 1 articles about 5,6-Dihydro-2H-pyran-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5,6-dihydro-2H-pyran-3-carbaldehyde (13417-49-7) → (S)-tetrahydropyran-3-yl-carboxaldehyde (14774-35-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; Ambient temperature;

DOI:10.1246/cl.1981.1183

Reference yield: 100.0%

(S)-tetrahydropyran-3-yl-carboxaldehyde (14774-35-7) → rac-(tetrahydro-2H-pyran-3-yl)methanol (14774-36-8)

Guidance literature:

With (1,5-cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; hydrogen; In dichloromethane; under 1500.15 Torr;

DOI:10.1002/chem.201104073

Reference yield: 99.0%

(S)-tetrahydropyran-3-yl-carboxaldehyde (14774-35-7) + 4-methoxy-benzoyl chloride (100-07-2) → 4-methoxy-benzoic acid 5,6-dihydro-2H-pyran-3-ylmethyl ester (756533-15-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2004.06.081

upstream raw materials:

5,6-dihydro-2H-pyran-3-carbaldehyde

Downstream raw materials:

3,5-dinitro-benzoic acid-(5,6-dihydro-2H-pyran-3-ylmethyl ester)

4-methoxy-benzoic acid 5,6-dihydro-2H-pyran-3-ylmethyl ester

4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester

4-Methoxy-benzoic acid (3aS,7aS)-2,2-dioxo-dihydro-2λ⁶-[1,3,2]dioxathiolo[4,5-c]pyran-3a-ylmethyl ester