4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester

Base Information

• Chemical Name: 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester
• CAS No.: 756533-16-1
• Molecular Formula: C₁₄H₁₈O₆
• Molecular Weight: 282.293

Synonyms:4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester

Chemical Property of 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester

Chemical Property:

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Technology Process of 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester

There total 3 articles about 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methoxy-benzoic acid 5,6-dihydro-2H-pyran-3-ylmethyl ester (756533-15-0) → 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester (756533-16-1)

Guidance literature:

With potassium osmate(VI); Hydroquinone 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); potassium carbonate; In tert-butyl alcohol;

DOI:10.1016/j.bmcl.2004.06.081

Reference yield:

(S)-tetrahydropyran-3-yl-carboxaldehyde (14774-35-7) → 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester (756533-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / Et₃N; DMAP / CH₂Cl₂

2: 90 percent / (DHQ)2PHAL; aq. K₂OsO₄; K₃Fe(CN)6 / K₂CO₃ / 2-methyl-propan-2-ol

With dmap; potassium osmate(VI); Hydroquinone 1,4-phthalazinediyl diether; triethylamine; potassium hexacyanoferrate(III); potassium carbonate; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2004.06.081

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) → 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester (756533-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / Et₃N; DMAP / CH₂Cl₂

2: 90 percent / (DHQ)2PHAL; aq. K₂OsO₄; K₃Fe(CN)6 / K₂CO₃ / 2-methyl-propan-2-ol

With dmap; potassium osmate(VI); Hydroquinone 1,4-phthalazinediyl diether; triethylamine; potassium hexacyanoferrate(III); potassium carbonate; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2004.06.081

upstream raw materials:

4-methoxy-benzoic acid 5,6-dihydro-2H-pyran-3-ylmethyl ester

(S)-tetrahydropyran-3-yl-carboxaldehyde

4-methoxy-benzoyl chloride

Downstream raw materials:

4-Methoxy-benzoic acid (3aS,7aS)-2,2-dioxo-dihydro-2λ⁶-[1,3,2]dioxathiolo[4,5-c]pyran-3a-ylmethyl ester

(3R,4R)-3-Hydroxymethyl-4-(2'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-ol

(3R,4R)-3-Hydroxymethyl-4-(4-p-tolyloxy-benzenesulfonyl)-tetrahydro-pyran-3-ol

(3S,4R)-3-Hydroxy-4-(2'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-carboxylic acid

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