Technology Process of (+)-Himbacine
There total 59 articles about (+)-Himbacine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: n-BuLi / 1,2-dimethoxy-ethane; hexane / 0.17 h / -78 °C
1.2: 45 percent / 1,2-dimethoxy-ethane; hexane / 1 h / -78 °C
2.1: 66 percent / Na-Hg; Na2HPO4 / methanol / 2.5 h / 20 °C
3.1: 100 percent / Jones reagent / acetone / 0.5 h / 20 °C
4.1: 100 percent / trifluoroacetic acid / CH2Cl2 / 1.5 h / 20 °C
5.1: 91 percent / NaBH3CN / acetonitrile / 0.5 h / 20 °C
With
disodium hydrogenphosphate; n-butyllithium; jones reagent; sodium amalgam; sodium cyanoborohydride; trifluoroacetic acid;
In
methanol; 1,2-dimethoxyethane; hexane; dichloromethane; acetone; acetonitrile;
1.2: Julia-Lythgoe reaction / 3.1: Jones oxidation;
DOI:10.1016/S0040-4020(02)01358-3
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 39 percent / RuO4; NaIO4 / ethyl acetate; H2O
2.1: 54 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 50 percent / LiCl; (i-Pr)2EtN / acetonitrile / 12 h
4.1: TFA / CH2Cl2 / 0 - 20 °C
4.2: NaCNBH3 / CH2Cl2; ethanol / 0.01 h / 20 °C
4.3: aq. NaHCO3 / CH2Cl2; ethanol / 20 °C
5.1: Et3N / CH2Cl2 / 14 h
6.1: 11 percent / H2 / PtO2 / ethanol / 12 h
7.1: 95 percent / TFA / CH2Cl2 / 1 h
8.1: 74 percent / sodium cyanoborohydride / acetonitrile; H2O / 1 h / 20 °C
With
sodium periodate; n-butyllithium; ruthenium tetroxide; hydrogen; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride;
platinum(IV) oxide;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2005.09.050
