1-Benzhydryl-N-methyl-3-azetidinamine

Base Information

• Chemical Name: 1-Benzhydryl-N-methyl-3-azetidinamine
• CAS No.: 69159-49-5
• Molecular Formula: C17H20N2
• Molecular Weight: 252.359
• Hs Code.: 2933990090
• Mol file: 69159-49-5.mol

Synonyms:1-(Diphenylmethyl)-N-methyl-3-azetidinamine;

Chemical Property of 1-Benzhydryl-N-methyl-3-azetidinamine

Chemical Property:

• Vapor Pressure: 4.84E-05mmHg at 25°C
• Boiling Point: 349°Cat760mmHg
• Flash Point: 128.6°C
• PSA: 15.27000
• Density: 1.1g/cm³
• LogP: 3.00840
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Diphenylmethyl-(3-methylamino)azetidine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzhydryl-N-methyl-3-azetidinamine

There total 3 articles about 1-Benzhydryl-N-methyl-3-azetidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzhydryl-3-azetidinyl methanesulfonate (33301-41-6) + methylamine (74-89-5) → 1-(diphenylmethyl)-3-(methylamino)azetidine (69159-49-5)

Guidance literature:

In water; acetonitrile;

DOI:10.1248/cpb.41.126

Reference yield:

1-benzhydryl-3-azetidinyl methanesulfonate (33301-41-6) → 1-(diphenylmethyl)-3-(methylamino)azetidine (69159-49-5)

Guidance literature:

With methylamine; In methanol;

Reference yield:

1-(diphenylmethyl)-3-hydroxyazetidine (18621-17-5) → 1-(diphenylmethyl)-3-(methylamino)azetidine (69159-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / Ambient temperature

2: propan-2-ol / 3 h / 70 °C

With triethylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00059a002

upstream raw materials:

1-benzhydryl-3-azetidinyl methanesulfonate

methylamine

1-(diphenylmethyl)-3-hydroxyazetidine

Downstream raw materials:

1-(diphenylmethyl)-3-azetidine

N-(1-benzhydryl-3-azetidino)-N-methylacetamide

N-(1-benzhydrylazetidin-3-yl)-N-methylcarbamic acid tert-butyl ester

3-(methylamino)azetidine dihydrochloride

Refernces

• 1、 -. "MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES". Page/Page column 122-123. . Retrieved 2008/12/05.
• 2、 -. "1,8 benzonaphthyridine derivatives and antimicrobial compositions". . . Retrieved 2008/06/13.