2-Propenoic acid, 2-(diethoxyphosphinyl)-3-(4-methoxyphenyl)-, ethyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 2-(diethoxyphosphinyl)-3-(4-methoxyphenyl)-, ethyl ester
• CAS No.: 14656-25-8
• Molecular Formula: C16H23 O6 P
• Molecular Weight: 342.324
• NSC Number: 637147
• Nikkaji Number: J1.302.081G
• Mol file: 14656-25-8.mol

Synonyms:NSC 102264;NSC 637147;2-Propenoic acid, 2-(diethoxyphosphinyl)-3-(4-methoxyphenyl)-, ethyl ester;NSC637147;14656-25-8;NSC102264;NSC-637147;SCHEMBL12270043;XBVPDVFEWHGDML-NTCAYCPXSA-N;ethyl (E)-2-diethoxyphosphoryl-3-(4-methoxyphenyl)prop-2-enoate;Ethyl 2-(diethoxyphosphoryl)-3-(4-methoxyphenyl)acrylate;3-(4-Methoxyphenyl)propenoic acid, 2-(diethoxyphosphinyl)-, ethyl ester;Ethyl (2E)-2-(diethoxyphosphoryl)-3-(4-methoxyphenyl)-2-propenoate #;(E)-1-(Ethoxycarbonyl)-2-(4-methoxyphenyl)vinylphosphonic acid diethyl ester

Chemical Property of 2-Propenoic acid, 2-(diethoxyphosphinyl)-3-(4-methoxyphenyl)-, ethyl ester

Chemical Property:

• Vapor Pressure: 6.48E-09mmHg at 25°C
• Boiling Point: 467.5°Cat760mmHg
• Flash Point: 249.8°C
• Density: 1.165g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 342.12322545
• Heavy Atom Count: 23
• Complexity: 430

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(=CC1=CC=C(C=C1)OC)P(=O)(OCC)OCC
• Isomeric SMILES: CCOC(=O)/C(=C\C1=CC=C(C=C1)OC)/P(=O)(OCC)OCC

Technology Process of 2-Propenoic acid, 2-(diethoxyphosphinyl)-3-(4-methoxyphenyl)-, ethyl ester

There total 1 articles about 2-Propenoic acid, 2-(diethoxyphosphinyl)-3-(4-methoxyphenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl phosphonate (762-04-9,123-22-8) + ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate (24393-56-4) → Triethyl-4-methoxybenzylidenphosphonoacetat (14656-25-8)

Guidance literature:

With manganese(III) triacetate dihydrate; acetic acid; at 60 ℃;

DOI:10.1021/acs.orglett.1c02795

Reference yield: 50.0%

Triethyl-4-methoxybenzylidenphosphonoacetat (14656-25-8) + trimethylsulphonium iodide (2181-42-2) + methyl iodide (74-88-4) → ethyl 2-diethylphosphonato-2-methyl-3-(4-methoxyphenyl)but-3-enoate

Guidance literature:

trimethylsulphonium iodide; With sodium methylsulfinylmethanide; In tetrahydrofuran; dimethyl sulfoxide; at -8 ℃; for 0.25h;

Triethyl-4-methoxybenzylidenphosphonoacetat; In tetrahydrofuran; dimethyl sulfoxide; at -8 - 20 ℃; for 3.25h;

methyl iodide; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 14h;

DOI:10.1039/b509102k

Reference yield:

Triethyl-4-methoxybenzylidenphosphonoacetat (14656-25-8) + trimethylsulfoxonium iodide (1774-47-6) → ethyl 1-(diethoxyphosphoryl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

Triethyl-4-methoxybenzylidenphosphonoacetat; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

DOI:10.1021/acs.orglett.1c02795

upstream raw materials:

Diethyl phosphonate

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate

Refernces