N4-[5-(4-chlorophenoxy)-6-methoxy-8-quinolyl]pentane-1,4-diamine

Base Information

Chemical Name:N4-[5-(4-chlorophenoxy)-6-methoxy-8-quinolyl]pentane-1,4-diamine
CAS No.:57514-26-8
Molecular Formula:C21H24 Cl N3 O2
Molecular Weight:385.89
Hs Code.:
NSC Number:305812
DSSTox Substance ID:DTXSID001164411
Nikkaji Number:J557.319J
ChEMBL ID:CHEMBL12440

Synonyms:57514-26-8;NSC305812;CHEMBL12440;NSC-305812;O(c1ccc(Cl)cc1)c2c(OC)cc(NC(C)CCCN)c3ncccc23;SCHEMBL4728414;DTXSID001164411;BDBM50478956;N4-[5-(4-chlorophenoxy)-6-methoxy-8-quinolyl]pentane-1,4-diamine;N^2-[5-(4-Chlorophenoxy)-6-methoxy-8-quinolinyl]-2,4-pentanediamine;N4-[5-(4-Chlorophenoxy)-6-methoxy-8-quinolinyl]-1,4-pentanediamine

Suppliers and Price of N4-[5-(4-chlorophenoxy)-6-methoxy-8-quinolyl]pentane-1,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N4-[5-(4-chlorophenoxy)-6-methoxy-8-quinolyl]pentane-1,4-diamine

Chemical Property:

Vapor Pressure:2.06E-12mmHg at 25°C
Boiling Point:556.3°Cat760mmHg
Flash Point:290.2°C
PSA：69.40000
Density:1.233g/cm³
LogP:6.00170
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:385.1557047
Heavy Atom Count:27
Complexity:434

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCCN)NC1=CC(=C(C2=C1N=CC=C2)OC3=CC=C(C=C3)Cl)OC

Technology Process of N4-[5-(4-chlorophenoxy)-6-methoxy-8-quinolyl]pentane-1,4-diamine

There total 7 articles about N4-[5-(4-chlorophenoxy)-6-methoxy-8-quinolyl]pentane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63460-40-2
N-{4-[5-(4-chloro-phenoxy)-6-methoxy-quinolin-8-ylamino]-pentyl}-phthalimide

: 57514-26-8
N⁴-(6-methoxy-5-(4-chlorophenoxy)quinolin-8-yl)pentane-1,4-diamine

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Reflux;
DOI:10.3390/molecules26133991

Reference yield:

: 85-81-4
6-methoxy-8-nitroquinoline

: 57514-26-8
N⁴-(6-methoxy-5-(4-chlorophenoxy)quinolin-8-yl)pentane-1,4-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 60 °C

2.1: lithium hydroxide monohydrate / dimethyl sulfoxide / 4 h / 100 °C

3.1: hydrogenchloride; tin / ethanol / 0.5 h / 0 - 20 °C

4.1: acetic acid / methanol / 2 h

4.2: 20 °C

5.1: hydrazine hydrate / ethanol / 1 h / Reflux

With hydrogenchloride; tin; N-chloro-succinimide; lithium hydroxide monohydrate; hydrazine hydrate; acetic acid; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3390/molecules26133991

Reference yield:

: 64992-86-5
5-chloro-6-methoxy-8-nitro-quinoline

: 57514-26-8
N⁴-(6-methoxy-5-(4-chlorophenoxy)quinolin-8-yl)pentane-1,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate / dimethyl sulfoxide / 4 h / 100 °C

2.1: hydrogenchloride; tin / ethanol / 0.5 h / 0 - 20 °C

3.1: acetic acid / methanol / 2 h

3.2: 20 °C

4.1: hydrazine hydrate / ethanol / 1 h / Reflux

With hydrogenchloride; tin; lithium hydroxide monohydrate; hydrazine hydrate; acetic acid; In methanol; ethanol; dimethyl sulfoxide;
DOI:10.3390/molecules26133991