N-benzyl-2-phenoxyacetamide

Base Information

• Chemical Name: N-benzyl-2-phenoxyacetamide
• CAS No.: 18861-15-9
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Mol file: 18861-15-9.mol

Synonyms:Phenoxy-essigsaeure-benzylamid;phenoxy-acetic acid benzylamide;N-BENZYL-2-PHENOXY-ACETAMIDE;N1-benzyl-2-phenoxyacetamide;C-Phenoxy-N-benzyl-acetamid;

Chemical Property of N-benzyl-2-phenoxyacetamide

Chemical Property:

• Vapor Pressure: 6.43E-09mmHg at 25°C
• Boiling Point: 467.6°Cat760mmHg
• Flash Point: 236.6°C
• PSA: 38.33000
• Density: 1.132g/cm³
• LogP: 2.77270

Purity/Quality:

98% ^*data from raw suppliers

N-benzyl-2-phenoxyacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2-phenoxyacetamide

There total 14 articles about N-benzyl-2-phenoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzylamine (100-46-9) + 2-phenoxyacetic acid (122-59-8) → N-benzyl-2-phenoxyacetamide (18861-15-9)

Guidance literature:

With zirconium(IV) chloride; In tetrahydrofuran; at 70 ℃; for 24h; Molecular sieve; Inert atmosphere;

DOI:10.1002/chem.201104055

Reference yield: 89.0%

phenoxyacetic acid ethyl ester (2555-49-9) + benzylamine (100-46-9) → N-benzyl-2-phenoxyacetamide (18861-15-9)

Guidance literature:

With iron(III) chloride; In neat (no solvent); at 80 ℃; Sealed tube;

DOI:10.3390/molecules25051040

Reference yield: 82.0%

benzyl azide (622-79-7) + 2-phenoxyacetic acid (122-59-8) → N-benzyl-2-phenoxyacetamide (18861-15-9)

Guidance literature:

With triphenylphosphine; at 180 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2011.03.069

upstream raw materials:

Phenoxyacetyl chloride

benzylamine

phenoxyacetic acid ethyl ester

methyl 2-phenoxyacetate

Downstream raw materials:

SKF 513 hydrochloride

2-[benzyl(2-phenoxyethyl)amino]-1-ethanol

N-(2-Phenoxyethyl)benzylamine

N-benzylphenoxythioacetamide

Refernces

• 1、 Mkhonazi, Blessing D.,Shandu, Malibongwe,Tshinavhe, Ronewa,Simelane, Sandile B.,Moshapo, Paseka T.. "Solvent-free iron(III) chloride-catalyzed direct amidation of esters". supporting information. . Retrieved 2020/03/17.
• 2、 Lundberg, Helena,Tinnis, Fredrik,Adolfsson, Hans. "Direct amide coupling of non-activated carboxylic acids and amines catalysed by zirconium(IV) chloride". supporting information; experimental part. p. 3822 - 3826. Retrieved 2012/05/20.