8-Methoxy-2-aminotetralin

Base Information

• Chemical Name: 8-Methoxy-2-aminotetralin
• CAS No.: 3880-77-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Hs Code.: 2922290090
• European Community (EC) Number: 676-110-3
• DSSTox Substance ID: DTXSID501311922
• ChEMBL ID: CHEMBL26688
• Mol file: 3880-77-1.mol

Synonyms:8-Methoxy-2-aminotetralin;3880-77-1;8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine;CHEMBL26688;2-amino-8-methoxytetralin;8-methoxytetralin-2-amine;D0L5YC;8-methoxy-2-amino-tetralin;SCHEMBL266921;RVKOHSCTEHZRRT-UHFFFAOYSA-N;DTXSID501311922;BDBM50016733;8-methoxy-2-aminotetralin, AldrichCPR;AB07674;PD033604;(S)-(-)-8-METHOXY2-AMINOTETRALIN;CS-0200159;FT-0645285;FT-0694805;1,2,3,4-TETRAHYDRO-ACRIDINE-9-CARBOXYLICACIDAMIDE

Chemical Property of 8-Methoxy-2-aminotetralin

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 309.1°Cat760mmHg
• PKA: 10.22±0.20(Predicted)
• Flash Point: 147.4°C
• PSA: 35.25000
• Density: 1.056g/cm³
• LogP: 2.21150
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

8-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1CC(CC2)N

Technology Process of 8-Methoxy-2-aminotetralin

There total 14 articles about 8-Methoxy-2-aminotetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ 8-methoxy-2-aminotetralin (3880-77-1,127253-44-5)

Guidance literature:

Reference yield: 48.0%

N-benzyl-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (81185-19-5) → 8-methoxy-2-aminotetralin (3880-77-1,127253-44-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; for 3h; under 2068.6 Torr;

DOI:10.1016/0223-5234(89)90160-8

Reference yield: 39.0%

8-methoxy-2-tetralone (5309-19-3) → 8-methoxy-2-aminotetralin (3880-77-1,127253-44-5)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; for 89h; Ambient temperature;

DOI:10.1021/jm00121a045

upstream raw materials:

8-methoxy-2-tetralone

8-(methyloxy)-3,4-dihydro-2(1H)-naphthalenone oxime

N-benzyl-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

1,7-Dihydroxynaphthalene

Downstream raw materials:

N-(1,2,3,4-tetrahydro,8-methoxy-2-naphthalenyl)-acetamide

N-<1,2,3,4-tetrahydro-8-methoxy-5-(phenylthio)-2-naphthalenyl>acetamide

1,2,3,4-tetrahydro-8-methoxy-N-ethyl-5-(phenylthio)-2-naphthalenamine hydrochloride

1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine