8-Methoxy-5-(methylthio)-2-tetralinamine

Base Information

Chemical Name:8-Methoxy-5-(methylthio)-2-tetralinamine
CAS No.:81998-18-7
Molecular Formula:C₁₂H₁₇NOS
Molecular Weight:223.339
Hs Code.:
Mol file:81998-18-7.mol

Synonyms:2-Amino-5-methylthio-8-methoxy-1,2,3,4-tetrahydronaphthalene;8-Methoxy-5-methylsulfanyl-1,2,3,4-tetrahydro-naphthalen-2-ylamine;1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine;

Suppliers and Price of 8-Methoxy-5-(methylthio)-2-tetralinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 8-Methoxy-5-(methylthio)-2-tetralinamine

Chemical Property:

PSA：60.55000
LogP:2.93340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-Methoxy-5-(methylthio)-2-tetralinamine

There total 6 articles about 8-Methoxy-5-(methylthio)-2-tetralinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5309-19-3
8-methoxy-2-tetralone

: 81998-18-7,86287-13-0
1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine

Guidance literature:: Multi-step reaction with 6 steps

1: 1 N NaOH / ethanol; H₂O / pH 8.2

2: 1.) B₂H₆, 2.) concd. HCl / 1.) THF, reflux, 3 h, 2.) reflux, 15 min

3: 2.5 N NaOH / CH₂Cl₂

4: 72 percent / silver trifluoroacetate, iodine / CH₂Cl₂ / 1 h / 25 °C

5: 98 percent / Cu₂O / dimethylformamide / 3 h / 80 °C

6: 1.) phosphorus pentachloride, pyridine / 1.) toluene, reflux, 2 h, 2.) MeOH, 25 deg C, overnight

With pyridine; copper(I) oxide; hydrogenchloride; sodium hydroxide; phosphorus pentachloride; iodine; silver trifluoroacetate; diborane; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00344a009

Reference yield:

: 3880-77-1,127253-44-5
8-methoxy-2-aminotetralin

: 81998-18-7,86287-13-0
1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine

Guidance literature:: Multi-step reaction with 4 steps

1: 2.5 N NaOH / CH₂Cl₂

2: 72 percent / silver trifluoroacetate, iodine / CH₂Cl₂ / 1 h / 25 °C

3: 98 percent / Cu₂O / dimethylformamide / 3 h / 80 °C

4: 1.) phosphorus pentachloride, pyridine / 1.) toluene, reflux, 2 h, 2.) MeOH, 25 deg C, overnight

With pyridine; copper(I) oxide; sodium hydroxide; phosphorus pentachloride; iodine; silver trifluoroacetate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00344a009

Reference yield:

: 80270-68-4,153221-21-7
N-(1,2,3,4-tetrahydro,8-methoxy-2-naphthalenyl)-acetamide

: 81998-18-7,86287-13-0
1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / silver trifluoroacetate, iodine / CH₂Cl₂ / 1 h / 25 °C

2: 98 percent / Cu₂O / dimethylformamide / 3 h / 80 °C

3: 1.) phosphorus pentachloride, pyridine / 1.) toluene, reflux, 2 h, 2.) MeOH, 25 deg C, overnight

With pyridine; copper(I) oxide; phosphorus pentachloride; iodine; silver trifluoroacetate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00344a009