1,2,3,4,6,7-Hexahydropyrrolo[3,2,1-jk][1,4]benzodiazepine

Base Information

Chemical Name:1,2,3,4,6,7-Hexahydropyrrolo[3,2,1-jk][1,4]benzodiazepine
CAS No.:28740-91-2
Molecular Formula:C₁₁H₁₄N₂
Molecular Weight:174.246
Hs Code.:2933990090
Mol file:28740-91-2.mol

Synonyms:1,2,4,5,6,7-Hexahydropyrrolo<3,2,1-jK><1,4>benzodiazepin;

Suppliers and Price of 1,2,3,4,6,7-Hexahydropyrrolo[3,2,1-jk][1,4]benzodiazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1,2,3,4,6,7-Hexahydropyrrolo[3,2,1-jk][1,4]benzodiazepine

Chemical Property:

Vapor Pressure:0.000147mmHg at 25°C
Boiling Point:332.3°Cat760mmHg
Flash Point:170.5°C
PSA：15.27000
Density:1.17g/cm³
LogP:1.54610

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,2,3,4,6,7-Hexahydropyrrolo[3,2,1-jk][1,4]benzodiazepine

There total 4 articles about 1,2,3,4,6,7-Hexahydropyrrolo[3,2,1-jk][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 2-(indolin-1-yl)ethanamine bis trifluoroacetic acid

: 28740-91-2
1,2,3,4,6,7-hexahydro-[1,4]diazepino[6,7,1-hi]indole

Guidance literature:: With trifluoroacetic acid; In methanol; at 80 ℃; for 1h;
DOI:10.1016/j.bmcl.2019.126929

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 46006-95-5
2-(2,3-dihydro-1H-indol-1-yl)ethanamine

: 28740-91-2
1,2,3,4,6,7-hexahydro-[1,4]diazepino[6,7,1-hi]indole

Guidance literature:: With trifluoroacetic acid; In ethanol; at 20 ℃; for 10h;
DOI:10.1021/acschemneuro.0c00520

Reference yield:

: 13708-58-2
2-indol-1-yl-ethylamine

: 28740-91-2
1,2,3,4,6,7-hexahydro-[1,4]diazepino[6,7,1-hi]indole

Guidance literature:: Multi-step reaction with 2 steps

1: borane pyridine; acetic acid / 8 h / 20 °C

2: trifluoroacetic acid / ethanol / 10 h / 20 °C

With borane pyridine; acetic acid; trifluoroacetic acid; In ethanol;
DOI:10.1021/acschemneuro.0c00520