2-(benzylamino)pyridine-3-carboxylic acid

Base Information

• Chemical Name: 2-(benzylamino)pyridine-3-carboxylic acid
• CAS No.: 33522-80-4
• Molecular Formula: C13H12N2O2
• Molecular Weight: 228.25
• Hs Code.: 2933399090
• Mol file: 33522-80-4.mol

Synonyms:2-(Benzylamino)nicotinic acid;2-(Phenylmethylamino)Pyridine-3-Carboxylic Acid;F2135-0897;Nicotinic acid,2-(benzylamino);S 216;2-(3-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXALDEHYDE;benzylaminonicotinicacid;2-[benzylamino]pyridine-3-carboxylic acid;

Chemical Property of 2-(benzylamino)pyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 5.01E-08mmHg at 25°C
• Melting Point: 233～234℃
• Boiling Point: 426.3°Cat760mmHg
• PKA: 1.65±0.36(Predicted)
• Flash Point: 211.6°C
• PSA: 62.22000
• Density: 1.301g/cm³
• LogP: 2.46490
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(Benzylamino)nicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzylamino)pyridine-3-carboxylic acid

There total 2 articles about 2-(benzylamino)pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloronicotinic acid (2942-59-8) + benzylamine (100-46-9) → 2-(benzylamino)nicotinic acid (33522-80-4)

Guidance literature:

DOI:10.1021/jm00119a010

Reference yield:

→ 2-(benzylamino)nicotinic acid (33522-80-4)

Guidance literature:

Nitril 4;

Reference yield: 69.8%

5-chloro-3,3-dimethylindoline (1243165-15-2) + 2-(benzylamino)nicotinic acid (33522-80-4) → C23H22ClN3O

Guidance literature:

With N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; Inert atmosphere;

upstream raw materials:

2-chloronicotinic acid

benzylamine

Downstream raw materials:

1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl acetate

1-benzyl-4-chloro-1,8-naphthyridin-2(1H)-one

1-benzyl-4-hydroxy-1,8-naphthyridin-2(1H)-one

1-benzyl-4-phenyl-1,8-naphthyridin-2(1H)-one