4(3H)-Quinazolinone, 2-methoxy-

Base Information

• Chemical Name: 4(3H)-Quinazolinone, 2-methoxy-
• CAS No.: 1011-24-1
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 1011-24-1.mol

Synonyms:2-methoxy-quinazolin-4-one;2-methoxy-3,4-dihydroquinazolin-4-one;2-methoxy-3H-quinazolin-4-one;2-methoxy-3,4-dihydro-4-oxoquinazoline;2-methoxyquinazolin-4-ol;2-Methoxy-3H-chinazolin-4-on;2-methoxy-4-quinazolinol;4(3H)-Quinazolinone,2-methoxy;2-Methoxyquinazolin-4(3H)-one;2-Methoxy-3,4-dihydro-4-oxo-chinazolin;

Chemical Property of 4(3H)-Quinazolinone, 2-methoxy-

Chemical Property:

• Vapor Pressure: 0.00093mmHg at 25°C
• Melting Point: 230-232℃
• Boiling Point: 303.5°Cat760mmHg
• Flash Point: 137.3°C
• PSA: 54.98000
• Density: 1.32g/cm³
• LogP: 0.93170
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxyquinazolin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4(3H)-Quinazolinone, 2-methoxy-

There total 20 articles about 4(3H)-Quinazolinone, 2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-Methoxy-5-phenyl-1,2,4-oxadiazole (3201-50-1) → 2-methoxy-3,4-dihydro-4-oxoquinazoline (1011-24-1) + N-(iminomethoxymethyl)benzamide (58476-79-2)

Guidance literature:

With 9,10-diphenylanthracene; In methanol; for 6h; Irradiation;

DOI:10.1021/jo990298f

Reference yield: 38.0%

methanol (67-56-1) + diethyl <(3,4-dihydro-4-oxo-2-quinazolinyl)thio>bicarbamate (81559-85-5) → 2-methoxy-3,4-dihydro-4-oxoquinazoline (1011-24-1) + diethyl hydrazodicarboxylate (4114-28-7) + 12H,15H-<1,3,4>thiadiazolo<2,3-b:5,4-b'>diquinazoline-12,15-dione (81559-83-3)

Guidance literature:

Mechanism;

Reference yield: 31.0%

methanol (67-56-1) + diethyl diazodicarboxylate (4143-61-7,218603-74-8) + 2-thioxo-2,3-dihydro-1H-quinazolin-4-one (13906-09-7) → 2-methoxy-3,4-dihydro-4-oxoquinazoline (1011-24-1) + diethyl hydrazodicarboxylate (4114-28-7) + 12H,15H-<1,3,4>thiadiazolo<2,3-b:5,4-b'>diquinazoline-12,15-dione (81559-83-3) + 2,2'-di-<4(3H)-quinazolidyl>-disulfide (81559-84-4)

Guidance literature:

1.)reflux, 3 h 2.)r.t., 2 h;

upstream raw materials:

2,4-dimethoxy-quinazoline

Cyan-imidoameisensaeuremethylester

2-carbomethoxyaniline

2-ethoxycarbonylaniline