N~1~,N~2~-Bis[(pyridin-2-yl)methyl]ethane-1,2-diamine

Base Information

• Chemical Name: N~1~,N~2~-Bis[(pyridin-2-yl)methyl]ethane-1,2-diamine
• CAS No.: 4608-34-8
• Molecular Formula: C14H18N4
• Molecular Weight: 242.324
• Hs Code.: 2933399090
• NSC Number: 176072
• DSSTox Substance ID: DTXSID10306404
• Nikkaji Number: J644.859C
• Wikidata: Q82053501
• ChEMBL ID: CHEMBL3310665
• Mol file: 4608-34-8.mol

Synonyms:4608-34-8;N,N'-bis(pyridin-2-ylmethyl)ethane-1,2-diamine;N~1~,N~2~-Bis[(pyridin-2-yl)methyl]ethane-1,2-diamine;[(pyridin-2-yl)methyl](2-{[(pyridin-2-yl)methyl]amino}ethyl)amine;NSC176072;dipicolylethylenediamine;1,2-Ethanediamine, N,N'-bis(2-pyridinylmethyl)-;SCHEMBL348655;CHEMBL3310665;DTXSID10306404;NSC-176072;N,N'-BIS-2-PYRIDYLMETHYL ETHYLENEDIAMINE

Chemical Property of N~1~,N~2~-Bis[(pyridin-2-yl)methyl]ethane-1,2-diamine

Chemical Property:

• Boiling Point: 390.3°Cat760mmHg
• PKA: 7.94±0.20(Predicted)
• Flash Point: 189.9°C
• PSA: 49.84000
• Density: 1.101g/cm³
• LogP: 2.13780
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 242.153146591
• Heavy Atom Count: 18
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

N,N'-BIS-2-PYRIDYLMETHYL ETHYLENEDIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CNCCNCC2=CC=CC=N2

Technology Process of N~1~,N~2~-Bis[(pyridin-2-yl)methyl]ethane-1,2-diamine

There total 8 articles about N~1~,N~2~-Bis[(pyridin-2-yl)methyl]ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine-2-carbaldehyde (1121-60-4) + ethylenediamine (107-15-3,85404-18-8) → N,N'-bis(2-pyridylmethyl)ethylenediamine (4608-34-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 2585.74 Torr;

DOI:10.1002/(SICI)1096-9888(199812)33:12<1209::AID-JMS738>3.0.CO;2-W

Reference yield: 100.0%

N,N'-(bis(pyridin-2-yl)formylidene)-1,2-ethanediamine (2847-14-5) → N,N'-bis(2-pyridylmethyl)ethylenediamine (4608-34-8)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1002/jccs.200800096

Reference yield: 99.0%

(1E,1’E)-N,N’-(ethane-1,2-diyl)bis(1-(pyridin-2-yl)methanimine) (2847-14-5) → N,N'-bis(2-pyridylmethyl)ethylenediamine (4608-34-8)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 2h;

DOI:10.1002/ejoc.201700772

upstream raw materials:

pyridine-2-carbaldehyde

ethylenediamine

(1E,1’E)-N,N’-(ethane-1,2-diyl)bis(1-(pyridin-2-yl)methanimine)

N,N'-(bis(pyridin-2-yl)formylidene)-1,2-ethanediamine

Downstream raw materials:

N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine

3,3'-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene))bis(2-hydroxy-5-methylbenzaldehyde)

2,2'-(2-phenylimidazolidine-1,3-diyl)bis(methylene)dipyridine

N¹-benzyl-N¹,N²-bis(pyridine-2-ylmethyl)ethane-1,2-diamine