1-Phenethylpiperidin-4-ol

Base Information

• Chemical Name: 1-Phenethylpiperidin-4-ol
• CAS No.: 3518-76-1
• Molecular Formula: C13H19 N O
• Molecular Weight: 205.3
• Hs Code.: 2933399090
• European Community (EC) Number: 222-527-7
• UNII: U62RHL2Y72
• DSSTox Substance ID: DTXSID90188669
• Nikkaji Number: J216.168K
• Wikidata: Q83060489
• Mol file: 3518-76-1.mol

Synonyms:1-Phenethylpiperidin-4-ol;3518-76-1;1-(2-Phenylethyl)piperidin-4-ol;N-phenethyl-4-hydroxy piperidine;1-(2-Phenylethyl)-4-piperidinol;4-Piperidinol,1-(2-phenylethyl)-;EINECS 222-527-7;1-phenethyl-4-hydroxypiperidine;U62RHL2Y72;N-(-PHENETHYL)-4-HYDROXY PIPERIDINE;Cambridge id 5427383;UNII-U62RHL2Y72;Oprea1_163158;4-hydroxy-N-phenethylpiperidine;SCHEMBL4255190;DTXSID90188669;HMS1581O11;MFCD00038874;AKOS009036139;AM85334;CS-0358226;FT-0629317;AB00085107-01;A874729;A1-20323;1-PHENETHYL-4-HYDROXYPIPERIDINE [NFLIS-DRUG]

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Chemical Property of 1-Phenethylpiperidin-4-ol

Chemical Property:

• Vapor Pressure: 2.99E-05mmHg at 25°C
• Melting Point: 95.5-98.5℃
• Boiling Point: 341.9°Cat760mmHg
• Flash Point: 123.8°C
• PSA: 23.47000
• Density: 1.064g/cm³
• LogP: 1.62370
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 205.146664230
• Heavy Atom Count: 15
• Complexity: 169

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCC1O)CCC2=CC=CC=C2
• Uses: 1-Phenethyl-4-piperidinol it is used in preparation of 1-Pyrrolidinyl Indane derivatives as Histamine H3 receptor antagonists useful in treatment of diseases.

Technology Process of 1-Phenethylpiperidin-4-ol

There total 4 articles about 1-Phenethylpiperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 1-phenyl-2-bromoethane (103-63-9) → (RS)-(+/-)-1-phenethylpiperidin-4-ol (3518-76-1)

Guidance literature:

With potassium carbonate; In toluene; at 110 ℃;

DOI:10.1016/j.ejmech.2007.06.012

Reference yield: 63.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + allylsilane (18191-59-8) + 2-phenylethan-1-amine, trifluoroacetate → (RS)-(+/-)-1-phenethylpiperidin-4-ol (3518-76-1)

Guidance literature:

In water; at 58 ℃;

DOI:10.3987/COM-97-8056

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) + phenylacetaldehyde (122-78-1) → (RS)-(+/-)-1-phenethylpiperidin-4-ol (3518-76-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bioorg.2019.103322

upstream raw materials:

formaldehyd

allylsilane

4-HYDROXYPIPERIDINE

1-phenyl-2-bromoethane

Downstream raw materials:

C₂₆H₂₉NO

acetoacetic acid-N-phenethyl-4-piperidinyl ester

1-(2-phenylethyl)-4-piperidinone

diphenyl-acetic acid-(1-phenethyl-[4]piperidyl ester)