N-(1,3-benzodioxol-5-yl)-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:N-(1,3-benzodioxol-5-yl)-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:5840-65-3
Molecular Formula:C15H10 O4
Molecular Weight:254.242
Hs Code.:
DSSTox Substance ID:DTXSID70360426
Wikidata:Q82142163

Synonyms:STK376894;CBMicro_034780;DTXSID70360426;AKOS005448224;N-(1,3-benzodioxol-5-yl)-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;BIM-0034710.P001;SR-01000550894;SR-01000550894-1;N-(1,3-benzodioxol-5-yl)-5-(thiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Suppliers and Price of N-(1,3-benzodioxol-5-yl)-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of N-(1,3-benzodioxol-5-yl)-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Chemical Property:

Density:1.66g/cm³
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:432.05039589
Heavy Atom Count:30
Complexity:657

Purity/Quality:: ≥99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1OC2=C(O1)C=C(C=C2)NC(=O)C3=C4N=C(C=C(N4N=C3)C(F)(F)F)C5=CC=CS5

Technology Process of N-(1,3-benzodioxol-5-yl)-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 5 articles about N-(1,3-benzodioxol-5-yl)-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 27550-59-0
4-hydroxyphthalic anhydride

: 100-39-0
benzyl bromide

: 5840-65-3
5-(benzyloxy)-2-benzofuran-1,3-dione

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 113h;
DOI:10.1055/s-0028-1083179

Reference yield:

: 610-35-5
4-hydroxyphthalic acid

: 5840-65-3
5-(benzyloxy)-2-benzofuran-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. KOH / 12 h / 120 °C

2: 60 percent / 1 h / 200 °C

With potassium hydroxide;
DOI:10.1248/cpb.54.1709

Reference yield:

: 100-39-0
benzyl bromide

: 5840-65-3
5-(benzyloxy)-2-benzofuran-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C

1.2: 6 h / Reflux

2.1: acetic anhydride / 2 h / 150 °C

With acetic anhydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.059