N'-Nitro-D-arginine

Base Information

• Chemical Name: N'-Nitro-D-arginine
• CAS No.: 66036-77-9
• Molecular Formula: C₆H₁₃N₅O₄
• Molecular Weight: 219.2
• Hs Code.: 2925290090
• Mol file: 66036-77-9.mol

Synonyms:NG-Nitro-D-arginine;Nw-Nitro-D-arginine;H-D-Arg(NO2)-OH;

Chemical Property of N'-Nitro-D-arginine

Chemical Property:

• Appearance/Colour: White to off white powder
• Melting Point: >220oC
• Refractive Index: 1.638
• Boiling Point: 462.4 °C at 760 mmHg
• Flash Point: 233.5 °C
• PSA: 157.05000
• Density: 1.65 g/cm³
• LogP: 0.58920
• Storage Temp.: Store at RT.

Purity/Quality:

97% ^*data from raw suppliers

N''-Nitro-D-arginine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N'-Nitro-D-arginine

There total 3 articles about N'-Nitro-D-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-methyl-N-nitroisourea (57538-27-9) + dihydrochloride of (S)-ornithine (6211-16-1,36630-89-4) → Nω-nitro-L-arginine (2149-70-4,66036-77-9,137433-32-0)

Guidance literature:

Multistep reaction; (i) CuCO₃, aq. NaOH, (ii) /BRN= 1906080/, aq. HCl, (iii) H₂S;

Reference yield:

→ Nω-nitro-L-arginine (2149-70-4,66036-77-9,137433-32-0)

Guidance literature:

L-Guanidin, KNO3, HF, 0grad;

DOI:10.1021/jo01277a072

Reference yield:

D-arginine hydrochloride (627-75-8) → Nω-nitro-D-arginine (66036-77-9,13855-78-2,38733-00-5)

Guidance literature:

With sulfuric acid; sulfur trioxide; nitric acid; Nitrogen dioxide;

upstream raw materials:

O-methyl-N-nitroisourea

dihydrochloride of (S)-ornithine

D-arginine hydrochloride

Downstream raw materials:

N-alpha-t-butoxycarbonyl-Ng-nitroarginine

N^α-benzyloxycarbonyl-N^g-nitro-L-arginine

N'-nitro-L-arginine benzyl ester

(S)-2-((S)-2-benzyloxycarbonylamino-3-phenylpropanoylamino)-5-nitroguanidinopentanoic acid