1-(Dimethylamino)-2-butanol

Base Information

• Chemical Name: 1-(Dimethylamino)-2-butanol
• CAS No.: 3760-96-1
• Molecular Formula: C6H15NO
• Molecular Weight: 117.1894
• Mol file: 3760-96-1.mol

Synonyms:

Chemical Property of 1-(Dimethylamino)-2-butanol

Chemical Property:

• Boiling Point: 157.8°Cat760mmHg
• Flash Point: 42.9°C
• PSA: 23.47000
• Density: 0.883g/cm³
• LogP: 0.31890

Purity/Quality:

99%min ^*data from raw suppliers

2-Butanol,1-(dimethylamino)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Dimethylamino)-2-butanol

There total 13 articles about 1-(Dimethylamino)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyloxirane (106-88-7) + dimethyl amine (124-40-3) → (+/-)-1-Dimethylamino-2-butanol (34487-37-1,3760-96-1)

Guidance literature:

dimethyl amine; With n-butyllithium; In tetrahydrofuran; at -78 - 23 ℃; Inert atmosphere;

ethyloxirane; In tetrahydrofuran; at -78 - 23 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.11.022

Reference yield: 69.0%

(2R,3R)-2,3-Bis-benzoyloxy-succinic acid; compound with (R)-1-dimethylamino-butan-2-ol (39010-59-8) → (R)-1-Dimethylamino-2-butanol (3760-97-2,3760-96-1)

Guidance literature:

In diethyl ether;

DOI:10.1055/s-1984-30884

Reference yield: 63.0%

(2R,3R)-2,3-Bis-benzoyloxy-succinic acid; compound with (S)-1-dimethylamino-butan-2-ol (93246-15-2) → (S)-1-Dimethylamino-2-butanol (34487-38-2,3760-96-1)

Guidance literature:

In diethyl ether;

DOI:10.1055/s-1984-30884

upstream raw materials:

1-(dimethylamino)but-3-en-2-ol

1-chloro-butan-2-ol

dimethyl amine

ethyloxirane

Refernces

• 1、 -. "KRAS G12C INHIBITORS". Paragraph 0183. . Retrieved 2017/12/18.
• 2、 Sard,Duffley,Robertson,Razdan. "Improved procedure for the preparation of chiral 1,2-epoxybutanes: Total synthesis of (S)-3'-hydroxy-Δ9-tetrahydrocannabinol, a highly active metabolite of Δ9-tetrahydrocannabinol". . p. 506 - 509. Retrieved 2007/10/02.