1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-benzoylhydroxypiperidine hydrochloride

Base Information

Chemical Name:1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-benzoylhydroxypiperidine hydrochloride
CAS No.:134826-28-1
Molecular Formula:C₂₂H₂₇NO₄*ClH
Molecular Weight:405.922
Hs Code.:
DSSTox Substance ID:DTXSID50158969
Mol file:134826-28-1.mol

Synonyms:134826-28-1;1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-benzoylhydroxypiperidine hydrochloride;1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-piperidinol benzoate (ester) hydrochloride;4-Piperidinol, 1-(2-(3,4-dimethoxyphenyl)ethyl)-, benzoate (ester), hydrochloride;[1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-4-yl] benzoate;hydrochloride;4-Piperidinol, 1-(2-(3,4-dimethoxyphenyl)ethyl)-, benzoate (ester), hy drochloride;DTXSID50158969;LYXUJZCAWIJHME-UHFFFAOYSA-N;LS-116992;4-Piperidinol,1-[2-(3,4-dimethoxyphenyl)ethyl]-,4-benzoate,hydrochloride(1:1)

Suppliers and Price of 1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-benzoylhydroxypiperidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-PIPERIDINOL, 1-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-, BENZOATE (ESTER), HY DROCHLORIDE 95.00%
5MG
$ 500.76

Total 4 raw suppliers

Chemical Property of 1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-benzoylhydroxypiperidine hydrochloride

Chemical Property:

Vapor Pressure:1.82E-09mmHg at 25°C
Melting Point:245-246 °C(Solv: ethanol (64-17-5))
Boiling Point:482.5°Cat760mmHg
Flash Point:245.6°C
PSA：48.00000
Density:g/cm³
LogP:4.30760
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:405.1706861
Heavy Atom Count:28
Complexity:444

Purity/Quality:

99% ^*data from raw suppliers

4-PIPERIDINOL, 1-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-, BENZOATE (ESTER), HY DROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCN2CCC(CC2)OC(=O)C3=CC=CC=C3)OC.Cl

Technology Process of 1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-benzoylhydroxypiperidine hydrochloride

There total 2 articles about 1-(2-(3,4-Dimethoxyphenyl)ethyl)-4-benzoylhydroxypiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 98-88-4
benzoyl chloride

: 134826-25-8
1-<2-(3,4-dimethoxyphenyl)ethyl>-4-hydroxypiperidine

: 134826-28-1
1-<2-(3,4-dimethoxyphenyl)ethyl>-4-benzoylhydroxypiperidine hydrochloride

Guidance literature:: at 50 - 60 ℃; for 10h;
DOI:10.1007/BF00772104

Reference yield:

: 3612-14-4
1-<2-(3,4-dimethoxyphenyl)ethyl>-4-piperidone

: 134826-28-1
1-<2-(3,4-dimethoxyphenyl)ethyl>-4-benzoylhydroxypiperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 99.9 percent / NaBH₄ / propan-2-ol / 1.) RT, 1 h, 2.) from 50 to 55 deg C, 1 h

2: 80 percent / 10 h / 50 - 60 °C

With sodium tetrahydroborate; In isopropyl alcohol;
DOI:10.1007/BF00772104