(2-Hydroxyphenyl)urea

Base Information

• Chemical Name: (2-Hydroxyphenyl)urea
• CAS No.: 1196-72-1
• Molecular Formula: C7H8 N2 O2
• Molecular Weight: 152.153
• NSC Number: 176141
• UNII: 7IM2K7AX1C
• DSSTox Substance ID: DTXSID1061605
• Nikkaji Number: J421.564H
• Wikidata: Q81989557
• ChEMBL ID: CHEMBL225487
• Mol file: 1196-72-1.mol

Synonyms:(2-Hydroxyphenyl)urea;1196-72-1;o-Hydroxyphenylurea;Urea, (2-hydroxyphenyl)-;2-Ureidophenol;2-hydroxyphenylurea;Urea, N-(2-hydroxyphenyl)-;N-(2-Hydroxyphenyl)urea;Urea, (o-hydroxyphenyl)-;7IM2K7AX1C;NSC 176141;NSC-176141;NSC176141;(o-Hydroxyphenyl)urea;UNII-7IM2K7AX1C;N-(2-Hydroxyphenyl)urea #;CHEMBL225487;SCHEMBL3859948;DTXSID1061605;AKOS022634774

Chemical Property of (2-Hydroxyphenyl)urea

Chemical Property:

• Vapor Pressure: 0.0024mmHg at 25°C
• Boiling Point: 279.2°Cat760mmHg
• Flash Point: 122.7°C
• PSA: 75.35000
• Density: 1.407g/cm³
• LogP: 1.65610
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 152.058577502
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NC(=O)N)O

Technology Process of (2-Hydroxyphenyl)urea

There total 12 articles about (2-Hydroxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

potassium cyanate (590-28-3) + 2-amino-phenol (95-55-6) → n-(2-hydroxy-benzene)-urea (1196-72-1)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c8ra03761b

Reference yield: 90.0%

2-amino-phenol (95-55-6) + urea (57-13-6) → n-(2-hydroxy-benzene)-urea (1196-72-1)

Guidance literature:

With hydrogenchloride; acetic acid; In water; for 2h; Reflux;

Reference yield: 47.9%

2-amino-phenol (95-55-6) → n-(2-hydroxy-benzene)-urea (1196-72-1)

Guidance literature:

In water; acetic acid;

upstream raw materials:

potassium cyanate

2-aminophenol hydrochloride

urea

potassium cyanide

Downstream raw materials:

2-Benzoxazolinone

C₁₇H₂₀N₄O₄

ethyl 2-ureidophenylcarbonate

p-nitrophenyl 2-ureidophenylcarbonate