Diphpetmednp

Base Information

• Chemical Name: Diphpetmednp
• CAS No.: 104305-93-3
• Molecular Formula: C35H36 N4 O6
• Molecular Weight: 608.68
• Mol file: 104305-93-3.mol

Synonyms:3,5-Pyridinedicarboxylicacid, 2,6-dimethyl-4-(3-nitrophenyl)-,2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI)

Chemical Property of Diphpetmednp

Chemical Property:

• Vapor Pressure: 1.15E-19mmHg at 25°C
• Boiling Point: 704°Cat760mmHg
• PKA: 5.91±0.10(Predicted)
• Flash Point: 379.6°C
• PSA: 117.79000
• Density: 1.238g/cm³
• LogP: 6.02320

Purity/Quality:

>95% ^*data from raw suppliers

2,6-Dimethyl-4-(3-nitrophenyl)-3,5-PyridinedicarboxylicAcid3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Dimethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl Ester, is a new 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect.

Technology Process of Diphpetmednp

There total 4 articles about Diphpetmednp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

Manidipine dihydrochloride (89226-75-5,119992-99-3,126229-12-7,126372-04-1) → 2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-dicarboxylate (104305-93-3)

Guidance literature:

With nitric acid; In 1,4-dioxane; at 70 ℃; for 1.5h;

DOI:10.1248/cpb.33.3787

Reference yield:

1-diphenylmethyl-4-(2-hydroxyethyl)piperazine (10527-64-7) → 2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-dicarboxylate (104305-93-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 739.8 g / 2 h / 70 - 80 °C

2: 20 percent NH₃/EtOH

3: 17.8 percent / propan-2-ol / 6 h / Heating

4: 90.1 percent / 2 N HNO₃ / dioxane / 1.5 h / 70 °C

With ethanol; ammonia; nitric acid; In 1,4-dioxane; isopropyl alcohol;

DOI:10.1248/cpb.33.3787

Reference yield:

2-(4-diphenylmethyl-1-piperazinyl)ethyl acetoacetate (89226-49-3) → 2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-dicarboxylate (104305-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 20 percent NH₃/EtOH

2: 17.8 percent / propan-2-ol / 6 h / Heating

3: 90.1 percent / 2 N HNO₃ / dioxane / 1.5 h / 70 °C

With ethanol; ammonia; nitric acid; In 1,4-dioxane; isopropyl alcohol;

DOI:10.1248/cpb.33.3787

upstream raw materials:

Manidipine dihydrochloride

1-diphenylmethyl-4-(2-hydroxyethyl)piperazine

2-(4-diphenylmethyl-1-piperazinyl)ethyl acetoacetate

2-(4-diphenylmethyl-1-piperazinyl)ethyl 3-aminocrotonate

Refernces