89226-49-3

Basic information

• Product Name: Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester
• CAS NO: 89226-49-3
• Molecular Formula: C23H28N2O3
• Molecular Weight: 380.487
• Mol File: 89226-49-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester(89226-49-3)
• EPA Substance Registry System: Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester(89226-49-3)

Safety Data

• Hazardous Substances Data: 89226-49-3(Hazardous Substances Data)

Usage

General Description

Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester, also known by its chemical formula C24H28N2O3, is a unique compound with a piperazine structure. This chemical is frequently used in pharmaceutical research and drug development due to its potential as a central nervous system agent. Its structure and properties make it an attractive candidate for the development of potential drugs and therapies. It is important to handle this compound with caution, as it is a potent chemical with potential biological activity and should only be used by trained professionals in a controlled laboratory setting.

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 10527-64-7 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine 
• 841-77-0 diphenylmethylpiperazine 
• 674-82-8 4-methyleneoxetan-2-one 

Downstream Products

• 89226-62-0 3-methyl 5-[2-(4-benzhydryl-1-piperazinyl)-ethyl] (+)-1,4-dihydro-2,6-dimethyl-4-(2-chlorophenyl)-pyridine-3,5-dicarboxylate 
• 142731-07-5 2,6-Dimethyl-4-(9-oxo-9H-xanthen-4-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzhydryl-piperazin-1-yl)-ethyl] ester 5-ethyl ester 
• 90095-77-5 2-(4-diphenylmethyl-1-piperazinyl)ethyl ethyl 4-(3-chlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 
• 89226-53-9 2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 98290-99-4 5-<2-(4-diphenylmethyl-1-piperazinyl)ethyl> 3-ethyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 89226-50-6 manidipine 
• 89226-75-5 Manidipine dihydrochloride 
• 104305-93-3 2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-dicarboxylate 
• 107610-45-7 5-<2-(4-benzhydrylpiperazin-1-yl)ethoxycarbonyl>-2-chloro-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine 
• 107610-30-0 5-[2-(4-benzhydrylpiperazin-1-yl)ethyl]oxycarbonyl-2-hydroxy-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine 
• 126397-25-9 2-Hydroxy-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 142731-06-4 2,6-Dimethyl-4-(9-oxo-9H-xanthen-4-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzhydryl-piperazin-1-yl)-ethyl] ester 5-methyl ester 
• 90096-10-9 4-Benzo[1,2,5]oxadiazol-4-yl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzhydryl-piperazin-1-yl)-ethyl] ester 5-methyl ester; hydrochloride 
• 89226-71-1 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Preparation method of manidipine hydrochloride

The invention discloses a preparation method of manidipine hydrochloride and belongs to the technical field of medicine preparation. Piperazine serving as a starting raw material is used for synthesis of N-(2-hydroxyethyl)piperazine, then 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine is synthesized, and 2-(4-diphenylmethyl-1-piperazinyl)ethyl acetoacetic ester is synthesized; 2-(4-diphenylmethyl-1-piperazinyl)ethyl acetoacetic ester, m-nitrobenzaldehyde and methyl 3-aminocrotonate are dissolved in isopropanol, the mixture is subjected to heating reflux, a solvent is removed through steaming, residues are dissolved in trichloromethane, the mixture is dried with anhydrous sodium sulfate and filtered, a solvent of the filtrate is recovered under reduced pressure, residues are mixed with methanol to be completely dissolved, hydrogen chloride is introduced in an ice bath, the solvent is removed through steaming, residues are mixed with methanol, activated carbon is added for decoloration, filtering is performed, filtrate is cooled, and manidipine hydrochloride is obtained. The preparation method of manidipine hydrochloride is simple in process, the yield is high, the cost is low, and the product purity is high.

Substituted heterocyclylalkyl esters of 1,4-dihydropyridine-3,5-dicarboxylic acids

Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula STR1 wherein R1, R2 and R3 are the same or different and each is alkyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; R4 and R5 are the same or different and each is hydrogen, halogen, nitro, trifluoromethyl, alkyl, cycloalkyl, alkoxy, cyano, alkoxycarbonyl or alkylthio; R6 is hydrogen, alkyl, cycloalkyl, aralkyl, aryl or a pyridyl; X is oxygen, sulfur, vinylene, azomethine or a group of the formula STR2 A is alkylene; Ar is aryl or a pyridyl; m is an integer of 1 to 3; n is an integer of 0 to 2.

New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect

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