2-(4-Benzhydrylpiperazin-1-yl)ethanol

Base Information

• Chemical Name: 2-(4-Benzhydrylpiperazin-1-yl)ethanol
• CAS No.: 10527-64-7
• Molecular Formula: C19H24N2O
• Molecular Weight: 296.412
• Hs Code.: 2933599090
• European Community (EC) Number: 812-114-5
• UNII: 9AMR7XC6Q8
• ChEMBL ID: CHEMBL1254795
• DSSTox Substance ID: DTXSID401283035
• Nikkaji Number: J313.863A
• Mol file: 10527-64-7.mol

Synonyms:10527-64-7;2-(4-benzhydrylpiperazin-1-yl)ethanol;Cetirizine alcohol;1-diphenylmethyl-4-(2-hydroxyethyl)piperazine;4-benzhydryl-1-piperazineethanol;1-Piperazineethanol, 4-(diphenylmethyl)-;9AMR7XC6Q8;4-(Diphenylmethyl)-1-piperazineethanol;UNII-9AMR7XC6Q8;2-(4-benzhydrylpiperazin-1-yl)ethan-1-ol;2-[4-(diphenylmethyl)piperazin-1-yl]ethan-1-ol;SCHEMBL1491229;CHEMBL1254795;QEYZAHKHYSGDJK-UHFFFAOYSA-N;DTXSID401283035;MFCD06742676;AKOS003588739;2-(4-benzhydryl piperazine-1-yl)ethanol;2-(4-benzhydryl piperazine-1-yl) ethanol;A1-50250

Chemical Property of 2-(4-Benzhydrylpiperazin-1-yl)ethanol

Chemical Property:

• Vapor Pressure: 1.333Pa at 180℃
• Boiling Point: 180 °C(Press: 0.01 Torr)
• PKA: 14.96±0.10(Predicted)
• PSA: 26.71000
• Density: 1.115±0.06 g/cm3(Predicted)
• LogP: 2.26170
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 296.188863393
• Heavy Atom Count: 22
• Complexity: 285

Purity/Quality:

99.9% ^*data from raw suppliers

2-(4-Benzhydrylpiperazin-1-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCO)C(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2-(4-Benzhydrylpiperazin-1-yl)ethanol

There total 7 articles about 2-(4-Benzhydrylpiperazin-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

1-(2-hydroxyethyl)piperazine (103-76-4) + Bromodiphenylmethane (776-74-9) → 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine (10527-64-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h;

Reference yield: 66.0%

diphenylmethylpiperazine (841-77-0) + 2-bromoethanol (540-51-2) → 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine (10527-64-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1248/cpb.43.797

Reference yield: 44.0%

→ N-methyl-N-4-(1H-2-methylimidazo[4,5-c]pyridinylmethyl)-phenylsulphonyl-L-leucine-2-(4-benzhydryl-piperazin-1-yl)-ethyl ester + 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine (10527-64-7)

Guidance literature:

upstream raw materials:

1-(2-hydroxyethyl)piperazine

diphenylchloromethane

diphenylmethylpiperazine

2-bromoethanol

Downstream raw materials:

3-[2-(4-benzhydryl-piperazino)-ethoxy]-propane-1,2-diol

manidipine

{1-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-5-iodo-1H-[1,2,3]triazol-4-yl}methanol

1-(2-azidoethyl)-4-benzhydrylpiperazine