Methyl 4,6-dihydroxynicotinate

Base Information

• Chemical Name: Methyl 4,6-dihydroxynicotinate
• CAS No.: 79398-27-9
• Molecular Formula: C₇H₇NO₄
• Molecular Weight: 169.137
• Hs Code.: 2933399090
• Mol file: 79398-27-9.mol

Synonyms:4,6-Dihydroxy-3-pyridinecarboxylicacid methyl ester;4,6-Dihydroxynicotinic acid methyl ester;Methyl4,6-dihydroxynicotinate;Methyl 4,6-dihydroxypyridine-3-carboxylate;NSC 112516;

Chemical Property of Methyl 4,6-dihydroxynicotinate

Chemical Property:

• Vapor Pressure: 1.71E-05mmHg at 25°C
• Melting Point: 252-255 ºC
• Refractive Index: 1.573
• Boiling Point: 325.9 ºC at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 150.9 ºC
• PSA: 79.65000
• Density: 1.456 g/cm³
• LogP: 0.27940
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

methyl4,6-dihydroxynicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4,6-dihydroxynicotinate

There total 9 articles about Methyl 4,6-dihydroxynicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → methyl 4,6-dihydroxypyridine-3-carboxylate (79398-27-9)

Guidance literature:

3-oxopentanedioic acid dimethyl ester; N,N-dimethyl-formamide dimethyl acetal; at 90 ℃; for 1.5h;

With ammonium hydroxide; In water; at 0 ℃; for 0.5h;

DOI:10.1021/ml500137b

Reference yield: 67.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) + orthoformic acid triethyl ester (122-51-0) → methyl 4,6-dihydroxypyridine-3-carboxylate (79398-27-9)

Guidance literature:

3-oxopentanedioic acid dimethyl ester; orthoformic acid triethyl ester; With acetic anhydride; acetic acid; at 120 ℃; for 1.5h;

With ammonia; In water; for 1h; Cooling with ice;

With hydrogenchloride; In water;

Reference yield: 53.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) → methyl 4,6-dihydroxypyridine-3-carboxylate (79398-27-9)

Guidance literature:

3-oxopentanedioic acid dimethyl ester; With acetic anhydride; orthoformic acid triethyl ester; at 130 ℃; for 1.5h;

With ammonia; In water; at 0 ℃; for 1h;

upstream raw materials:

2-[1-Ethoxy-meth-(Z)-ylidene]-3-oxo-pentanedioic acid dimethyl ester

3-oxopentanedioic acid dimethyl ester

dimethyl acetylmalonate

trimethyl orthoformate

Downstream raw materials:

methyl 4,6-dichloropyridine-3-carboxylate

6-chloro-4-methoxypyridine-3-carbaldehyde

(6-chloro-4-methoxypyridin-3-yl)methanol

4,6-dimethoxy-nicotinic acid methyl ester