N-(2-(dimethylamino)ethyl)-5-methyl-4-acridinecarboxamide

Base Information

• Chemical Name: N-(2-(dimethylamino)ethyl)-5-methyl-4-acridinecarboxamide
• CAS No.: 106626-72-6
• Molecular Formula: C₁₉H₂₁N₃O
• Molecular Weight: 307.395
• Hs Code.: 2934999090
• Mol file: 106626-72-6.mol

Synonyms:N-(2-(dimethylamino)ethyl)-5-methyl-4-acridinecarboxamide

Chemical Property of N-(2-(dimethylamino)ethyl)-5-methyl-4-acridinecarboxamide

Chemical Property:

• Vapor Pressure: 2.49E-12mmHg at 25°C
• Boiling Point: 554.4°Cat760mmHg
• Flash Point: 289.1°C
• PSA: 48.72000
• Density: 1.163g/cm³
• LogP: 3.56260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-(dimethylamino)ethyl)-5-methyl-4-acridinecarboxamide

There total 2 articles about N-(2-(dimethylamino)ethyl)-5-methyl-4-acridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9,10-dihydro-5-methyl-9-oxo-4-acridinecarboxylic acid (24782-66-9) → 5-Methyl-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide (106626-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Al(Hg), KOH, 2.) 12N HCl, FeCl₃ / 1.) 50percent aq. EtOH, reflux, 2.) 50percent aq. EtOH, reflux

2: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 20 deg C, 2.) DMF, 0 deg C, 5 min

With hydrogenchloride; potassium hydroxide; aluminum amalgam; iron(III) chloride; 1,1'-carbonyldiimidazole;

DOI:10.1021/jm00387a014

Reference yield:

5-methylacridine-4-carboxylic acid (32602-26-9) + N,N-dimethylethylenediamine (108-00-9) → 5-Methyl-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide (106626-72-6)

Guidance literature:

With 1,1'-carbonyldiimidazole; Yield given. Multistep reaction; 1.) DMF, 20 deg C, 2.) DMF, 0 deg C, 5 min;

DOI:10.1021/jm00387a014

upstream raw materials:

5-methylacridine-4-carboxylic acid

N,N-dimethylethylenediamine

9,10-dihydro-5-methyl-9-oxo-4-acridinecarboxylic acid