24782-66-9Relevant academic research and scientific papers
Anticancer anilinoacridines. A process synthesis of the disubstituted amsacrine analog CI-921
Brennan,Colbry,Leeds,Leja,Priebe,Reily,Showalter,Uhlendorf,Atwell,Denny
, p. 1469 - 1476 (2007/10/02)
An improved process for the synthesis of bulk quantities of the clinical amsacrine analog CI-921 is reported. Described also are detailed analytical and spectroscopic data for this agent.
Potential Antitumor Agents. 46. Structure-Activity Relationships for Acridine Monosubstituted Derivatives of the Antitumor Agent N--9-aminoacridine-4-carboxamide
Rewcastle, Gordon W.,Atwell, Graham J.,Chambers, David,Baguley, Bruce C.,Denny, William A.
, p. 472 - 477 (2007/10/02)
A series of monosubstituted derivatives of the new antitumor agent N--9-aminoacridine-4-carboxamide has been prepared, bearing methyl, methoxy, and chloro groups at available acridine positions.The physicochemical properties and an
Potential antitumor agents. 40. Orally active 4,5-disubstituted derivatives of amsacrine
Denny,Atwell,Baguley
, p. 363 - 367 (2007/10/02)
The DNA-intercalating agent amsacrine is an effective drug for the treatment of human leukemias and lymphomas but has minimal solid tumor activity. As a first step in identifying analogues with a wider spectrum of activity, a comparison was made of the in
Compound having antitumor properties
-
, (2008/06/13)
The compound 4'-(9-[4-[N-methyl-carboxamido]-5-methyl]acridinylamino)methanesulphon-m-anisidide and acid addition salts thereof have antitumor properties.
