alpha-((4-Aminophenoxy)methyl)-4-phenyl-1-piperidineethanol

Base Information

Chemical Name:alpha-((4-Aminophenoxy)methyl)-4-phenyl-1-piperidineethanol
CAS No.:64511-68-8
Molecular Formula:C20H26 N2 O2
Molecular Weight:326.439
Hs Code.:
DSSTox Substance ID:DTXSID90983116

Synonyms:BRN 1689530;alpha-((4-Aminophenoxy)methyl)-4-phenyl-1-piperidineethanol;1-Piperidineethanol, alpha-((4-aminophenoxy)methyl)-4-phenyl-;64511-68-8;DTXSID90983116;1-(4-aminophenoxy)-3-(4-phenylpiperidin-1-yl)propan-2-ol;LS-115333

Suppliers and Price of alpha-((4-Aminophenoxy)methyl)-4-phenyl-1-piperidineethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of alpha-((4-Aminophenoxy)methyl)-4-phenyl-1-piperidineethanol

Chemical Property:

Vapor Pressure:1.98E-12mmHg at 25°C
Melting Point:105 °C
Boiling Point:538.6°Cat760mmHg
PKA:14.23±0.20(Predicted)
Flash Point:279.5°C
PSA：58.72000
Density:1.148g/cm³
LogP:3.40720
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:326.199428076
Heavy Atom Count:24
Complexity:344

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C2=CC=CC=C2)CC(COC3=CC=C(C=C3)N)O

Technology Process of alpha-((4-Aminophenoxy)methyl)-4-phenyl-1-piperidineethanol

There total 4 articles about alpha-((4-Aminophenoxy)methyl)-4-phenyl-1-piperidineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 64511-67-7
1-(4-nitrophenoxy)-3-(N-4-phenylpiperidine)-2-propanol

: 64511-68-8
1-(4-aminophenoxy)-3-(N-4-phenylpiperidine)-2-propanol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1h; under 760 Torr;
DOI:10.1021/jm00109a007

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 64511-68-8
1-(4-aminophenoxy)-3-(N-4-phenylpiperidine)-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1 N NaOH / 10 h

2: 83 percent / ethanol / 4 h / Heating

3: 96 percent / H₂ / 10percent Pd/C / ethanol / 1 h / 760 Torr

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00109a007

Reference yield:

: 125228-75-3
4-nitrophenyl 2-oxiranylmethyl ether

: 64511-68-8
1-(4-aminophenoxy)-3-(N-4-phenylpiperidine)-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / ethanol / 4 h / Heating

2: 96 percent / H₂ / 10percent Pd/C / ethanol / 1 h / 760 Torr

With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00109a007