2-CHLORO-10-(CHLOROACETYL)-10H-PHENOTHIAZINE

Base Information

• Chemical Name: 2-CHLORO-10-(CHLOROACETYL)-10H-PHENOTHIAZINE
• CAS No.: 16189-69-8
• Molecular Formula: C14H9 Cl2 N O S
• Molecular Weight: 310.204
• Hs Code.: 2934300000
• Mol file: 16189-69-8.mol

Synonyms:10H-Phenothiazine,2-chloro-10-(chloroacetyl)- (9CI); Phenothiazine, 2-chloro-10-(chloroacetyl)-(6CI,8CI); 2-Chloro-1-(2-chlorophenothiazin-10-yl)ethanone;2-Chloro-10-(chloroacetyl)phenothiazine; NSC 241506

Chemical Property of 2-CHLORO-10-(CHLOROACETYL)-10H-PHENOTHIAZINE

Chemical Property:

• Vapor Pressure: 1.01E-11mmHg at 25°C
• Boiling Point: 539.9°Cat760mmHg
• Flash Point: 280.3°C
• PSA: 45.61000
• Density: 1.468g/cm³
• LogP: 4.77310

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-1-(2-chloro-10H-phenothiazin-10-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-10-(CHLOROACETYL)-10H-PHENOTHIAZINE

There total 3 articles about 2-CHLORO-10-(CHLOROACETYL)-10H-PHENOTHIAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chlorophenothiazine (92-39-7) + chloroacetyl chloride (79-04-9) → 2-chloro-1-(2-chloro-10H-phenothiazin-10-yl)ethan-1-one (16189-69-8)

Guidance literature:

In toluene; at 0 - 80 ℃; for 12h;

DOI:10.1016/j.ejmech.2015.10.035

Reference yield:

3-chlorodiphenylamine (101-17-7) → 2-chloro-1-(2-chloro-10H-phenothiazin-10-yl)ethan-1-one (16189-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; sulfur

2: benzene

With iodine; sulfur; benzene;

Reference yield:

→ 2-chloro-1-(2-chloro-10H-phenothiazin-10-yl)ethan-1-one (16189-69-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at -10 - 0 ℃; for 3h;

upstream raw materials:

2-chlorophenothiazine

chloroacetyl chloride

3-chlorodiphenylamine

Downstream raw materials:

1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]-1H-pyrrole-2,5-dione

1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]pyrrolidine-2,5-dione

2-chloro-10-(2'-chloroethyl)-10H-phenothiazine

4-trifluoromethoxy-N-(2-(2-chloro-10H-phenothiazin-10-yl)ethyl)benzenesulfonamide

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