2-methoxy-6-(4-methoxybenzyl)pyrimidin-4-amine

Base Information

• Chemical Name: 2-methoxy-6-(4-methoxybenzyl)pyrimidin-4-amine
• CAS No.: 143467-65-6
• Molecular Formula: C13H15 N3 O2
• Molecular Weight: 245.2771
• Mol file: 143467-65-6.mol

Synonyms:

Chemical Property of 2-methoxy-6-(4-methoxybenzyl)pyrimidin-4-amine

Chemical Property:

• Vapor Pressure: 4.38E-08mmHg at 25°C
• Boiling Point: 444.2°Cat760mmHg
• Flash Point: 222.4°C
• Density: 1.193g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methoxy-6-(4-methoxybenzyl)pyrimidin-4-amine

There total 4 articles about 2-methoxy-6-(4-methoxybenzyl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-chloro-2-methoxy-6-(4-methoxybenzyl)pyrimidine (143467-63-4) → 2-Methoxy-6-(4-methoxy-benzyl)-pyrimidin-4-ylamine (143467-65-6)

Guidance literature:

With ammonium hydroxide; In N,N-dimethyl-formamide; for 36h; Ambient temperature;

DOI:10.1016/0223-5234(92)90009-P

Reference yield:

6-(4-methoxybenzyl)-2-methoxy-4(3H)-pyrimidinone (143467-62-3) → 2-Methoxy-6-(4-methoxy-benzyl)-pyrimidin-4-ylamine (143467-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / POCl₃ / CHCl₃; dimethylformamide / 24 h

2: 88 percent / 32percent NH₄OH / dimethylformamide / 36 h / Ambient temperature

With ammonium hydroxide; trichlorophosphate; In chloroform; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(92)90009-P

Reference yield:

4-methoxyphenyl-acetic chloride (4693-91-8) → 2-Methoxy-6-(4-methoxy-benzyl)-pyrimidin-4-ylamine (143467-65-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, n-hexane, from -70 to 5 deg C, 2.) THF, n-hexane, -65 deg C, 1 h

2: 73 percent / aq. Ca(OH)2 / ethanol / 36 h / Ambient temperature

3: 68 percent / POCl₃ / CHCl₃; dimethylformamide / 24 h

4: 88 percent / 32percent NH₄OH / dimethylformamide / 36 h / Ambient temperature

With calcium hydroxide; ammonium hydroxide; n-butyllithium; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(92)90009-P

upstream raw materials:

4-chloro-2-methoxy-6-(4-methoxybenzyl)pyrimidine

6-(4-methoxybenzyl)-2-methoxy-4(3H)-pyrimidinone

ethyl 4-(4-methoxylphenyl)-3-oxobutanoate

4-methoxyphenyl-acetic chloride

Refernces