4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER
• CAS No.: 32711-91-4
• Molecular Formula: C13H16 O4
• Molecular Weight: 236.268
• Hs Code.: 2918990090
• Mol file: 32711-91-4.mol

Synonyms:Acetoaceticacid, 4-(p-methoxyphenyl)-, ethyl ester (7CI,8CI); Ethyl4-(p-methoxyphenyl)acetoacetate

Chemical Property of 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER

Chemical Property:

• PSA: 52.60000
• LogP: 1.76000
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

ethyl4-(4-methoxyphenyl)-3-oxobutanoate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER

There total 14 articles about 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl bromoacetate (105-36-2) + p-methoxybenzylnitrile (104-47-2) → ethyl 4-(4-methoxylphenyl)-3-oxobutanoate (32711-91-4)

Guidance literature:

ethyl bromoacetate; p-methoxybenzylnitrile; With methanesulfonic acid; zinc; In tetrahydrofuran; for 0.5h;

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1055/s-2004-831197

Reference yield: 91.0%

→ ethyl 4-(4-methoxylphenyl)-3-oxobutanoate (32711-91-4)

Guidance literature:

Reference yield: 87.0%

cycl-isopropylidene malonate (2033-24-1) + ethanol (64-17-5) + 4-methoxyphenyl-acetic chloride (4693-91-8) → ethyl 4-(4-methoxylphenyl)-3-oxobutanoate (32711-91-4)

Guidance literature:

cycl-isopropylidene malonate; 4-methoxyphenyl-acetic chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

ethanol; for 2h; Heating;

DOI:10.1021/ja060729t

upstream raw materials:

ethanol

5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

hydrogen ethyl malonate

4-methoxyphenyl-acetic chloride

Downstream raw materials:

6-(4-methoxybenzyl)-2-(benzyloxy)-4-(2-methylcyclohexyloxy)-3-(prop-1-en-2-yl)pyridine

Refernces

• 1、 Han, Zhengyu,Huang, Hai,Meng, Fuliang,Yang, Zhenkun,Zhang, Tianyu,Zhou, Dapeng. "Non-metal Lewis acid-catalyzed cross-Claisen condensation for β-keto esters". supporting information. p. 9163 - 9166. Retrieved 2021/11/16.
• 2、 Wang, Hsiao-Chun,Jagtap, Ajit Dhananjay,Chang, Pei-Teh,Liu, Jia-Rong,Liu, Chih-Peng,Tseng, Hsiang-Wen,Chen, Grace Shiahuy,Chern, Ji-Wang. "Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor". . p. 312 - 334. Retrieved 2014/08/05.