N-(5-tert-butyl-4-{[6-hydroxy-2-(1-methylethyl)-4-oxo-2-(2-phenylethyl)-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-3-cyanobenzenesulfonamide

Base Information

Chemical Name:N-(5-tert-butyl-4-{[6-hydroxy-2-(1-methylethyl)-4-oxo-2-(2-phenylethyl)-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-3-cyanobenzenesulfonamide
CAS No.:263842-71-3
Molecular Formula:C₃₄H₃₈N₂O₅S₂
Molecular Weight:618.818
Hs Code.:

N-(5-tert-butyl-4-{[6-hydroxy-2-(1-methylethyl)-4-oxo-2-(2-phenylethyl)-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-3-cyanobenzenesulfonamide

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-tert-butyl-4-{[6-hydroxy-2-(1-methylethyl)-4-oxo-2-(2-phenylethyl)-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-3-cyanobenzenesulfonamide

Chemical Property:

Vapor Pressure:1.16E-20mmHg at 25°C
Boiling Point:701.6°Cat760mmHg
Flash Point:378.1°C
PSA：150.17000
Density:1.29g/cm³
LogP:8.95498

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(5-tert-butyl-4-{[6-hydroxy-2-(1-methylethyl)-4-oxo-2-(2-phenylethyl)-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-3-cyanobenzenesulfonamide

There total 4 articles about N-(5-tert-butyl-4-{[6-hydroxy-2-(1-methylethyl)-4-oxo-2-(2-phenylethyl)-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-3-cyanobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 249728-38-9
4-hydroxy-6-isopropyl-6-phenethyl-5,6-dihydro-pyran-2-one

: 263843-13-6
toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(3-cyanobenzenesulfonylamino)-5-methyl-phenyl] ester

: 263842-71-3
N-[5-tert-Butyl-4-(4-hydroxy-6-isopropyl-2-oxo-6-phenethyl-5,6-dihydro-2H-pyran-3-ylsulfanyl)-2-methyl-phenyl]-3-cyano-benzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm990281p

Reference yield:

: 40463-09-0
4-methyl-1-phenylpentan-3-one

: 263842-71-3
N-[5-tert-Butyl-4-(4-hydroxy-6-isopropyl-2-oxo-6-phenethyl-5,6-dihydro-2H-pyran-3-ylsulfanyl)-2-methyl-phenyl]-3-cyano-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

2: 55 percent / K₂CO₃ / dimethylformamide / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; 2: Substitution;
DOI:10.1021/jm990281p

Reference yield:

: 56542-67-7
3-cyanobenzene sulfonyl chloride

: 263842-71-3
N-[5-tert-Butyl-4-(4-hydroxy-6-isopropyl-2-oxo-6-phenethyl-5,6-dihydro-2H-pyran-3-ylsulfanyl)-2-methyl-phenyl]-3-cyano-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / pyridine / CH₂Cl₂ / 20 °C

2: 55 percent / K₂CO₃ / dimethylformamide / 20 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Sulfonylation / 2: Substitution;
DOI:10.1021/jm990281p