2-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)ACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)ACETAMIDE
• CAS No.: 3608-86-4
• Molecular Formula: C13H14ClN3O2
• Molecular Weight: 279.726
• Hs Code.: 2933199090
• Mol file: 3608-86-4.mol

Synonyms:Acetamide,N-antipyrinyl-2-chloro- (8CI);Antipyrine, 4-(2-chloroacetamido)- (6CI,7CI);4-(Chloroacetamido)antipyrine;NSC 59997;

Chemical Property of 2-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)ACETAMIDE

Chemical Property:

• Refractive Index: 1.628
• PSA: 56.03000
• Density: 1.36 g/cm³
• LogP: 1.73470

Purity/Quality:

98%min ^*data from raw suppliers

2-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-ACETAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)ACETAMIDE

There total 2 articles about 2-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + chloroacetyl chloride (79-04-9) → 4-chloroacetylamino-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole (3608-86-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

→ 4-chloroacetylamino-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole (3608-86-4)

Guidance literature:

Phenazon-4-ylamin (Ia), Chloracetylchlorid/Benzol;

Reference yield: 92.0%

4-chloroacetylamino-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole (3608-86-4) + 4-Phenyl-5-o-tolyloxymethyl-4H-[1,2,4]triazole-3-thiol (76111-25-6) → 4-[(3-(2-methylphenoxymethyl)-4-phenyl-1,2,4-triazol-5-yl)thioacetamido]antipyrine

Guidance literature:

With potassium carbonate; In acetone; for 4h; Heating;

DOI:10.1016/S0223-5234(01)01252-1

upstream raw materials:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

chloroacetyl chloride

Downstream raw materials:

N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-morpholin-4-yl-acetamide

N,N-dimethyl-glycine 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamide

3,3-Diphenyl-5-ethoxycarbonyl-2-oxoindoline-1-acet-4-antipyrylamide

3,3-Diphenyl-4-ethoxycarbonyl-2-oxoindoline-1-acet-4-antipyrylamide