2-methoxy-4-(prop-2-en-1-yl)phenyl chloroacetate

Base Information

• Chemical Name: 2-methoxy-4-(prop-2-en-1-yl)phenyl chloroacetate
• CAS No.: 305-12-4
• Molecular Formula: C12H13 Cl O3
• Molecular Weight: 240.686
• Mol file: 305-12-4.mol

Synonyms:Aceticacid, chloro-, 2-methoxy-4-(2-propenyl)phenyl ester (9CI); Acetic acid,chloro-, 4-allyl-2-methoxyphenyl ester (7CI,8CI); NSC 8235

Chemical Property of 2-methoxy-4-(prop-2-en-1-yl)phenyl chloroacetate

Chemical Property:

• Vapor Pressure: 0.00103mmHg at 25°C
• Boiling Point: 301.8°C at 760 mmHg
• Flash Point: 115.4°C
• Density: 1.163g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methoxy-4-(prop-2-en-1-yl)phenyl chloroacetate

There total 3 articles about 2-methoxy-4-(prop-2-en-1-yl)phenyl chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-allylguaiacol (97-53-0) + chloroacetyl chloride (79-04-9) → eugenyl chloroacetate (305-12-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

4-allylguaiacol (97-53-0) + chloroacetic acid (79-11-8) → eugenyl chloroacetate (305-12-4)

Guidance literature:

With dmap; cerium(III) chloride heptahydrate; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 12.5h;

DOI:10.1134/S1070363220080265

Reference yield:

→ eugenyl chloroacetate (305-12-4)

Guidance literature:

Eugenol, 1-Chlor-acetylchlorid in wss. NaOH;

upstream raw materials:

4-allylguaiacol

chloroacetyl chloride

chloroacetic acid

Downstream raw materials:

2-methoxy-4-(2-propenyl)phenyl-2-[2(2,6-dichlorophenylamino)phenyl]ethanoyloxy ethanoate

Refernces

• 1、 Mahdavi, M.,Mostafavi, H.,Shahbazi, A.,Zarrini, G.. "Novel N-4-Piperazinyl Ciprofloxacin-Ester Hybrids: Synthesis, Biological Evaluation, and Molecular Docking Studies". . p. 1558 - 1565. Retrieved 2020/09/21.
• 2、 Iqbal,Ashraf,Hassan, Mubashir,Abbas,Jabeen, Erum. "Substituted phenyl[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetates/acetamides as alkaline phosphatase inhibitors: Synthesis, computational studies, enzyme inhibitory kinetics and DNA binding studies". . . Retrieved 2019/07/09.