2-(2-Thienyl)ethyl methanesulphonate

Base Information

• Chemical Name: 2-(2-Thienyl)ethyl methanesulphonate
• CAS No.: 61380-07-2
• Molecular Formula: C7H10 O3 S2
• Molecular Weight: 206.287
• Hs Code.: 2934999090
• European Community (EC) Number: 262-747-0
• DSSTox Substance ID: DTXSID80210302
• Nikkaji Number: J279.618J
• Wikidata: Q83084969
• Mol file: 61380-07-2.mol

Synonyms:61380-07-2;2-(2-Thienyl)ethyl methanesulphonate;2-thiophen-2-ylethyl methanesulfonate;2-(Thiophen-2-yl)ethyl methanesulfonate;2-Thiopheneethanol Methanesulfonate;EINECS 262-747-0;2-(Thien-2-yl)ethyl Methanesulfonate;2-(2-THIENYL)ETHYL METHANESULFONATE;2-(2-Thienyl)ethyl Mesylate;SCHEMBL1161703;C7H10O3S2;DTXSID80210302;VUMFRFIVUQTAPJ-UHFFFAOYSA-N;2-thien-2-ylethyl Methanesulfonate;C7-H10-O3-S2;2-(2-thienyl)ethyl methane-sulfonate;2-thiophen-2-yl-ethyl methansulfonate;AKOS030240761;2-(2-Thienyl)ethanol O-methanesulfonate;FT-0675172;Methanesulfonic acid 2-(2-thienyl)ethyl ester;F1916-6881

Chemical Property of 2-(2-Thienyl)ethyl methanesulphonate

Chemical Property:

• Vapor Pressure: 2.93E-05mmHg at 25°C
• Refractive Index: 1.546
• Boiling Point: 367.2°C at 760 mmHg
• Flash Point: 175.9°C
• PSA: 79.99000
• Density: 1.325g/cm³
• LogP: 2.34760
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 206.00713652
• Heavy Atom Count: 12
• Complexity: 217

Purity/Quality:

98%Min ^*data from raw suppliers

2-ThiopheneethanolMethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)OCCC1=CC=CS1
• Uses: An intermediate in the preparation of Sufentanil

Technology Process of 2-(2-Thienyl)ethyl methanesulphonate

There total 5 articles about 2-(2-Thienyl)ethyl methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-thiophenethanol (5402-55-1) + methanesulfonyl chloride (124-63-0) → 2-(thiophen-2-yl)ethyl methanesulfonate (61380-07-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 10 ℃; for 1h;

Reference yield: 92.0%

→ 2-(thiophen-2-yl)ethyl methanesulfonate (61380-07-2)

Guidance literature:

Reference yield:

2-thiophenethanol (5402-55-1) → 2-(thiophen-2-yl)ethyl methanesulfonate (61380-07-2)

Guidance literature:

With triethylamine; In dichloromethane; di-isopropyl ether;

upstream raw materials:

2-thiophenethanol

methanesulfonyl chloride

triethylamine

Thiophene-2-acetic acid

Downstream raw materials:

(S)-(+)-clopidogrel

2-(4-chlorophenyl)-4-(thien-2-yl)butyronitrile

thiofentanyl

N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride

Refernces

• 1、 Lebel, Hélène,Mathieu, Gary,Patel, Heena. "Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides". . p. 2157 - 2168. Retrieved 2020/11/23.
• 2、 Chaturvedi, Radha Nandan,Pendem, Krishnaiah,Patel, Vipul P.,Sharma, Mukta,Malhotra, Sunita. "Design, synthesis, molecular docking, and in vitro antidiabetic activity of novel PPARγ agonist". . p. 2069 - 2084. Retrieved 2018/08/22.