N-Methyl-2-(thiophen-2-YL)ethanamine

Base Information

• Chemical Name: N-Methyl-2-(thiophen-2-YL)ethanamine
• CAS No.: 106891-32-1
• Molecular Formula: C7H11 N S
• Molecular Weight: 141.23
• Hs Code.: 2934999090
• European Community (EC) Number: 808-392-2
• DSSTox Substance ID: DTXSID30331177
• Wikidata: Q82096133
• Mol file: 106891-32-1.mol

Synonyms:106891-32-1;N-METHYL-2-(THIOPHEN-2-YL)ETHANAMINE;METHYL-(2-THIOPHEN-2-YL-ETHYL)-AMINE;N-methyl-2-thiophen-2-ylethanamine;methyl[2-(thiophen-2-yl)ethyl]amine;N-methyl-2-(thiophen-2-yl)ethan-1-amine;N-methyl-2-(2-thienyl)ethanamine;Methyl-(2-thiophen-2-yl-ethyl)amine;SCHEMBL680547;DTXSID30331177;IKSCPAWBLQEUAG-UHFFFAOYSA-N;AMY21331;MFCD04114520;AKOS000259703;AB18501;AT16732;N-methyl-N-(2-(2-thienyl)ethyl)amine;CS-0217931;FT-0683192;EN300-93489;A801528;Methyl-(2-thiophen-2-yl-ethyl)-amine, AldrichCPR;Z162416950

Chemical Property of N-Methyl-2-(thiophen-2-YL)ethanamine

Chemical Property:

• PSA: 40.27000
• LogP: 1.90090
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 141.06122053
• Heavy Atom Count: 9
• Complexity: 75.3

Purity/Quality:

98%min ^*data from raw suppliers

N-Methyl-2-thiopheneethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCC1=CC=CS1
• Uses: N-Methyl-2-thiopheneethanamine is used to prepare DNA-dependent protein.

Technology Process of N-Methyl-2-(thiophen-2-YL)ethanamine

There total 7 articles about N-Methyl-2-(thiophen-2-YL)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(thiophen-2-yl)ethyl methanesulfonate (61380-07-2) + methylamine (74-89-5) → N-methyl-N-(2-(thien-2-yl)ethyl)amine (106891-32-1)

Guidance literature:

2-(thiophen-2-yl)ethyl methanesulfonate; methylamine; In methanol; water; at 140 ℃; for 0.166667h; under 15514.9 Torr; Flow reactor;

With potassium hydroxide; In water;

DOI:10.1021/acs.oprd.0c00193

Reference yield: 42.0%

thiophene-2-sulfonic acid (2-bromo-ethyl)-methyl-amide → N-methyl-N-(2-(thien-2-yl)ethyl)amine (106891-32-1) + thiophene-2-sulfonic acid ethyl-methyl-amide

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 12h; Heating;

DOI:10.1039/b303728b

Reference yield:

N-(2-(thien-2-yl)ethyl)formamide (28783-49-5) → N-methyl-N-(2-(thien-2-yl)ethyl)amine (106891-32-1)

Guidance literature:

With methanol; sodium tetrahydroborate; iodine; In tetrahydrofuran; at 7 - 20 ℃; for 16.6h;

upstream raw materials:

2-(2-Bromoethyl)thiophene

2-thiophenethanol

N-(2-(thien-2-yl)ethyl)formamide

[2-(2-thyenyl)ethyl]amine

Downstream raw materials:

{1-[3-(methyl-{1-[methyl-(2-thiophen-2-yl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-phenyl]-ethyl}-carbamic acid tert-butyl ester

(3E)-4-(N-((1R)-2-(biphenyl-4-yl)-1-(N-methyl-N-(2-(thien-2-yl)ethyl)carbamoyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester

N-((1R)-2-(biphenyl-4-yl)-1-(N-methyl-N-(2-(2-thienyl)ethyl)carbamoyl)ethyl)-N-methylcarbamic acid tert-butyl ester

Refernces

• 1、 Lebel, Hélène,Mathieu, Gary,Patel, Heena. "Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides". . p. 2157 - 2168. Retrieved 2020/11/23.
• 2、 -. "Compounds with growth hormone releasing properties". Example 4. . Retrieved 2010/01/31.