(2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE

Base Information

• Chemical Name: (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE
• CAS No.: 357-83-5
• Molecular Formula: C6H11ClF3N
• Molecular Weight: 189.608
• Hs Code.: 29211999
• Mol file: 357-83-5.mol

Synonyms:Triethylamine,2-chloro-1,1,2-trifluoro- (6CI,7CI,8CI);(1,1,2-Trifluoro-2-chloro)triethylamine;1-Diethylamino-1,1-difluoro-2-chloro-2-fluoroethane;2-Chloro-1,1,2-trifluoroethyldiethylamine;2-Chloro-1,1,2-trifluorotriethylamine;2-Chloro-N,N-diethyl-1,1,2-trifluoroethylamine;N-(1,1,2-Trifluoro-2-chloroethyl)diethylamine;N-(2-Chloro-1,1,2-trifluoroethyl)diethylamine;N-(2-Chloro-2-fluoro-1,1-difluoroethyl)diethylamine;Reagents, Yarovenko's;Yarovenko's reagent;Ethanamine,2-chloro-N,N-diethyl-1,1,2-trifluoro-;

Chemical Property of (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE

Chemical Property:

• Appearance/Colour: Clear brown liquid
• Vapor Pressure: 24.4mmHg at 25°C
• Refractive Index: 1.392
• Boiling Point: 109.8 °C at 760 mmHg
• PKA: 1.30±0.70(Predicted)
• Flash Point: 20.2 °C
• Density: 1.163 g/cm³
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99%, ^*data from raw suppliers

N,N-Diethyl(2-chloro-1,1,2-trifluoroethyl)amine 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 36/37/38-34-10
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE

There total 4 articles about (2-CHLORO-1,1,2-TRIFLUOROETHYL)DIETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,2-dibromo-1-chloro-1,2,2-trifluoroethane (354-51-8) + diethylamine (109-89-7) → N-(2-chloro-1,1,2-trifluoroethyl)diethylamine (357-83-5) + (2-Bromo-2-chloro-1,1,2-trifluoro-ethyl)-diethyl-amine (113939-50-7)

Guidance literature:

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; at -5 ℃; for 6h;

DOI:10.1016/S0040-4039(00)96359-7

Reference yield: 60.0%

adduct of (1,1,2-trifluoro-2-chloroethyl)diethylamine with trimethylsilyl isocyanate (1:2) (75988-27-1) → N-(2-chloro-1,1,2-trifluoroethyl)diethylamine (357-83-5) + trimethylsilyl isocyanate (1118-02-1) + N-fluorocarbonyl-N'-diethylchlorofluoroacetamidine (75988-34-0)

Guidance literature:

In diethyl ether; at 20 ℃; for 24h;

Reference yield: 45.0%

→ N-(2-chloro-1,1,2-trifluoroethyl)diethylamine (357-83-5)

Guidance literature:

upstream raw materials:

Chlorotrifluoroethylene

diethylamine

adduct of (1,1,2-trifluoro-2-chloroethyl)diethylamine with trimethylsilyl isocyanate (1:2)

1,2-dibromo-1-chloro-1,2,2-trifluoroethane

Downstream raw materials:

acetyl fluoride

chloro-fluoro-thioacetic acid diethylamide

propionyl fluoride

butanoyl fluoride

Refernces

A Novel One-step Procedure for the Conversion of Thymidine into 2,3'-Anhydrothymidine

10.1039/c39890000997

T. Sudhakar Rao and Colin B. Reese describe a new method for synthesizing 2,3'-anhydrothymidine (3), a key intermediate in the production of the antiretroviral drug 3'-azido-3'-deoxythymidine (AZT). The authors discovered that heating thymidine (2) with an excess of diphenyl sulphite in dimethylacetamide solution in the presence of a catalytic amount of 1-methylimidazole at 156°C for 45 minutes yields 2,3'-anhydrothymidine (3) in approximately 65% yield. This method is advantageous over previous procedures, such as the use of 2-chloro-1-diethylamino-1,1,2-trifluoroethane, due to the greater accessibility of diphenyl sulphite. The synthesized 2,3'-anhydrothymidine (3) can then be converted into AZT by reacting with lithium azide, achieving a 71% yield of AZT. This streamlined synthesis offers a more efficient route for the production of AZT, which is crucial for the treatment of AIDS patients.

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