Ethyl-1,3-dihydroxy-2-naphtoate

Base Information

• Chemical Name: Ethyl-1,3-dihydroxy-2-naphtoate
• CAS No.: 6843-89-6
• Molecular Formula: C13H12O4
• Molecular Weight: 232.236
• Hs Code.: 2918290000
• Mol file: 6843-89-6.mol

Synonyms:2-Naphthoicacid, 1,3-dihydroxy-, ethyl ester (6CI,7CI,8CI);1,3-Dihydroxy-2-naphthalenecarboxylic acid ethyl ester;2-Carbethoxy-1,3-dihydroxynaphthalene;Ethyl 1,3-dihydroxy-2-naphthoate;Ethyl1,3-dihydroxynaphthalene-2-carboxylate;NSC 68182;

Chemical Property of Ethyl-1,3-dihydroxy-2-naphtoate

Chemical Property:

• Vapor Pressure: 3.59E-06mmHg at 25°C
• Melting Point: 82 °C
• Refractive Index: 1.656
• Boiling Point: 375.5 °C at 760 mmHg
• PKA: 7.47±0.50(Predicted)
• Flash Point: 144 °C
• PSA: 66.76000
• Density: 1.328 g/cm³
• LogP: 2.42770
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl1,3-Dihydroxy-2-naphthoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl-1,3-dihydroxy-2-naphtoate

There total 5 articles about Ethyl-1,3-dihydroxy-2-naphtoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) + diethyl 1,3-acetonedicarboxylate (105-50-0) → ethyl 1,3-dihydroxy-2-naphthoate (6843-89-6)

Guidance literature:

With cesium fluoride; In acetonitrile; at 80 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Inert atmosphere;

DOI:10.1021/acs.joc.8b02560

Reference yield: 70.0%

diethyl 2-(2-phenylacetyl)malonate (20320-59-6) → ethyl 1,3-dihydroxy-2-naphthoate (6843-89-6)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 20 ℃;

DOI:10.1002/anie.201903492

Reference yield:

→ ethyl 1,3-dihydroxy-2-naphthoate (6843-89-6)

Guidance literature:

With sulfuric acid;

upstream raw materials:

diethyl 2-(2-phenylacetyl)malonate

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

diethyl 1,3-acetonedicarboxylate

Downstream raw materials:

1,3-dihydroxynaphthalene

1,3-dimethoxynaphthalene

1,3-dihydroxy-[2]naphthoic acid

Refernces

• 1、 Ghotekar, Ganesh S.,Shaikh, Aslam C.,Muthukrishnan. "Transition-Metal-Free Benzannulation of Tricarbonyl Derivatives with Arynes: Access to 1,3-Dinaphthol Precursors for the Synthesis of Rhodamine Dye Analogues". . p. 2269 - 2276. Retrieved 2019/05/16.
• 2、 -. "Novel Inhibitors of Hepatitis C Virus Replication". Page/Page column 52-53. . Retrieved 2009/10/21.