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whmulei fast and safe delivery cas 20320-59-6 diethyl 2-(2-phenylacetyl)propanedioate china supplier
Cas No: 20320-59-6
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Propanedioic acid, (phenylacetyl)-, diethyl ester
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20320-59-6 B oil B powder Diethyl(phenylacetyl)malonate
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USD $ 60.0-80.0 / Metric Ton 1 Metric Ton 1000 Kilogram/Day Shanghai Terui OP New Material Technology Co., Ltd. Contact Supplier
Cas 20320-59-6 safe delivery Propanedioic acid, (phenylacetyl)-, diethyl ester
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Diethyl(phenylacetyl)malonate/20320-59-6
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20320-59-6 Usage

Uses

Organic synthesis intermediates.

Preparation

The anhydrous ethanol co-vaporized with diethyl phthalate and sodium metal is added dropwise to the mixture of diethyl malonate, carbon tetrachloride and magnesium, heated to start the reaction, and the temperature is controlled to smooth the reaction. Then add anhydrous diethyl ether, heat for 1h, add the diethyl ether solution of phenylacetyl chloride (add slowly, not to make the reaction too intense). After the reaction is completed, cool and add water, separate the oil layer, and evaporate the diethyl ether under reduced pressure to obtain diethyl(phenylacetyl)malonate.

20320-59-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name diethyl 2-(2-phenylacetyl)propanedioate

1.2 Other means of identification

Product number -
Other names Phenylacetylmalonic acid ethylester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20320-59-6 SDS

20320-59-6Synthetic route

phenylacetyl chloride
103-80-0

phenylacetyl chloride

diethyl malonate
105-53-3

diethyl malonate

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
Stage #1: diethyl malonate With ethanol; magnesium In tetrachloromethane; toluene for 1h; Heating;
Stage #2: phenylacetyl chloride In tetrachloromethane; toluene at 20℃; for 1h;
90%
With chloroform; magnesium
With magnesium
sodium diethylmalonate
996-82-7

sodium diethylmalonate

phenylacetyl chloride
103-80-0

phenylacetyl chloride

A

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

B

(α-phenylacetoxy-phenethylidene)-malonic acid diethyl ester

(α-phenylacetoxy-phenethylidene)-malonic acid diethyl ester

Conditions
ConditionsYield
diethyl ethoxymagnesium malonate

diethyl ethoxymagnesium malonate

phenylacetyl chloride
103-80-0

phenylacetyl chloride

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
With diethyl ether; ethanol
diethyl malonate
105-53-3

diethyl malonate

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
With sodium dann mit Phenylessigsaeurechlorid versetzen;
C7H11O4(1-)*C2H5O(1-)*Mg(2+)

C7H11O4(1-)*C2H5O(1-)*Mg(2+)

phenylacetyl chloride
103-80-0

phenylacetyl chloride

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
diethyl acetylmalonate
570-08-1

diethyl acetylmalonate

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 24 percent / NH2NH2 / ethanol / 3 h / Heating
2.1: Mg; EtOH / CCl4; toluene / 1 h / Heating
2.2: 90 percent / CCl4; toluene / 1 h / 20 °C
View Scheme
ethyl 3-amino-2-ethoxycarbonyl-2-butenoate
137786-67-5

ethyl 3-amino-2-ethoxycarbonyl-2-butenoate

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 14 percent / 80 percent NH2NH2 / ethanol / 3 h / Heating
2.1: Mg; EtOH / CCl4; toluene / 1 h / Heating
2.2: 90 percent / CCl4; toluene / 1 h / 20 °C
View Scheme
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 3.5 h / 20 °C / Cooling with ice
2: 3 h / Reflux
View Scheme
phenylacetyl chloride
103-80-0

phenylacetyl chloride

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 3.5 h / 20 °C / Cooling with ice
2: 3 h / Reflux
View Scheme
ethanol
64-17-5

ethanol

2,2-dimethyl-5-(2-phenylacetyl)-1,3-dioxane-4,6-dione
74965-87-0

2,2-dimethyl-5-(2-phenylacetyl)-1,3-dioxane-4,6-dione

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
for 3h; Reflux;
phenylacetic acid
103-82-2

phenylacetic acid

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / dichloromethane / 1 h / 50 °C
2.1: sodium hydride / tetrahydrofuran / 1 h
2.2: 1 h / 0 - 20 °C
View Scheme
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

ethyl 5-benzyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate

ethyl 5-benzyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With hydrazine hydrate In acetic acid for 3h; Heating;81%
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

ethyl 1,3-dihydroxy-2-naphthoate
6843-89-6

ethyl 1,3-dihydroxy-2-naphthoate

Conditions
ConditionsYield
With methanesulfonic acid; phosphorus pentoxide at 20℃;70%
With methanesulfonic acid at 30℃; for 48h;
With sulfuric acid at 25℃;
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

aniline
62-53-3

aniline

2,N-diphenylacetamide
621-06-7

2,N-diphenylacetamide

Conditions
ConditionsYield
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

recorcinol
108-46-3

recorcinol

4-benzyl-7-hydroxycoumarin
20280-94-8

4-benzyl-7-hydroxycoumarin

Conditions
ConditionsYield
With hydrogenchloride; acetic acid; zinc(II) chloride
With sulfuric acid
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

phenylmethanethiol
100-53-8

phenylmethanethiol

2-Benzylmercapto-3-phenyl-1-propen-1,1-dicarbonsaeure
20597-30-2

2-Benzylmercapto-3-phenyl-1-propen-1,1-dicarbonsaeure

Conditions
ConditionsYield
(i) ZnCl2, HCl, (ii) NaOH; Multistep reaction;
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

2-Naphthalenesulfonyl chloride
93-11-8

2-Naphthalenesulfonyl chloride

Naphthalin-2-sulfonsaeure-<1-benzyl-2,2-diaethoxycarbonyl-vinyl-ester>
101981-93-5

Naphthalin-2-sulfonsaeure-<1-benzyl-2,2-diaethoxycarbonyl-vinyl-ester>

Conditions
ConditionsYield
With ethanol; sodium ethanolate
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

5-hydroxy-3-methylpyrazole
132712-71-1, 4344-87-0, 145091-87-8

5-hydroxy-3-methylpyrazole

A

2-benzyl-3-ethoxycarbonyl-7-methylpyrazolo<5,1-b><1,3>oxazin-5(5H)-one
91614-52-7

2-benzyl-3-ethoxycarbonyl-7-methylpyrazolo<5,1-b><1,3>oxazin-5(5H)-one

B

3-benzyl-2-ethoxycarbonyl-5-methylpyrazolo<1,2-a>pyrazole-1,7(1H,7H)-dione
91614-65-2

3-benzyl-2-ethoxycarbonyl-5-methylpyrazolo<1,2-a>pyrazole-1,7(1H,7H)-dione

C

3-benzyl-2-ethoxycarbonyl-7-methylpyrazolo<1,2-a>pyrazole-1,5(1H,5H)-dione
91614-73-2

3-benzyl-2-ethoxycarbonyl-7-methylpyrazolo<1,2-a>pyrazole-1,5(1H,5H)-dione

Conditions
ConditionsYield
at 150 - 160℃; for 0.25h;A 0.067 g
B 0.073 g
C 1.06 g
sulfuric acid
7664-93-9

sulfuric acid

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

1.3-dioxy-naphthoic acid-(2)-ethyl ester

1.3-dioxy-naphthoic acid-(2)-ethyl ester

Conditions
ConditionsYield
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

alcoholic potash

alcoholic potash

A

phenylacetic acid
103-82-2

phenylacetic acid

B

malonic acid
141-82-2

malonic acid

Conditions
ConditionsYield
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

acetic acid
64-19-7

acetic acid

phenylhydrazine
100-63-0

phenylhydrazine

1-phenyl-3-benzyl-pyrazolone-(5)

1-phenyl-3-benzyl-pyrazolone-(5)

Conditions
ConditionsYield
ethanol
64-17-5

ethanol

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

hydrochloride of hydroxylamine

hydrochloride of hydroxylamine

natrium carbonate

natrium carbonate

3-benzyl-isoxazolone-(5)-carboxylic acid-(4)-ethyl ester

3-benzyl-isoxazolone-(5)-carboxylic acid-(4)-ethyl ester

Conditions
ConditionsYield
hydrogenchloride
7647-01-0

hydrogenchloride

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

1-phenyl-acetone
103-79-7

1-phenyl-acetone

Conditions
ConditionsYield
diethyl ether
60-29-7

diethyl ether

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

phenylhydrazine
100-63-0

phenylhydrazine

A

diethyl malonate
105-53-3

diethyl malonate

B

phenacetyl-phenylhydrazine

phenacetyl-phenylhydrazine

C

1-phenyl-3-benzyl-pyrazolone-(5)-carboxylic acid-(4)-ethyl ester

1-phenyl-3-benzyl-pyrazolone-(5)-carboxylic acid-(4)-ethyl ester

Conditions
ConditionsYield
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

2-benzyl-3-ethoxycarbonyl-7-methylpyrazolo<5,1-b><1,3>oxazin-5(5H)-one
91614-52-7

2-benzyl-3-ethoxycarbonyl-7-methylpyrazolo<5,1-b><1,3>oxazin-5(5H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.06 g / 0.25 h / 150 - 160 °C
2: 75 percent / acetonitrile / 2 h / Irradiation
View Scheme
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Naphthalin-2-sulfonsaeure-<1-benzyl-2,2-dicarboxy-vinyl-ester>

Naphthalin-2-sulfonsaeure-<1-benzyl-2,2-dicarboxy-vinyl-ester>

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOEt, EtOH
2: aq. NaOH
View Scheme
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

2-Benzylsulfinyl-3-phenyl-1-propen-1,1-dicarbonsaeure
20597-37-9

2-Benzylsulfinyl-3-phenyl-1-propen-1,1-dicarbonsaeure

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) ZnCl2, HCl, (ii) NaOH
2: AcOOH
View Scheme
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

2-Benzylsulfonyl-3-phenyl-1-propen-1,1-dicarbonsaeure
20597-44-8

2-Benzylsulfonyl-3-phenyl-1-propen-1,1-dicarbonsaeure

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) ZnCl2, HCl, (ii) NaOH
2: AcOOH
View Scheme
diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

A

ethyl 3-ethoxy-5-benzyl-1H-pyrazole-4-carboxylate
1207432-20-9

ethyl 3-ethoxy-5-benzyl-1H-pyrazole-4-carboxylate

B

ethyl 5-benzyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate

ethyl 5-benzyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With hydrazine hydrochloride In ethanol for 6h; Reflux;A 2.3 g
B n/a
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