trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid

Base Information

• Chemical Name: trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid
• CAS No.: 324756-11-8
• Molecular Formula: C₁₄H₁₈FNO₄S
• Molecular Weight: 315.366
• Mol file: 324756-11-8.mol

Synonyms:trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid

Chemical Property of trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid

There total 1 articles about trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluorobenzenesulfonyl chloride (2905-21-7) + trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid (324756-11-8)

Guidance literature:

With sodium hydroxide; In chloroform; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2003.10.001

Reference yield:

trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid (324756-11-8) → 4-[(2-fluoro-benzenesulfonylamino)-methyl]-cyclohexanecarboxylic acid (6-fluoro-1-pyridin-3-ylmethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-amide

Guidance literature:

trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Further stages.;

DOI:10.1021/jm990468g

Reference yield:

trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid (324756-11-8) + (cis)-1,2,3,4-tetrahydro-6-methoxy-1-(3-pyridinylmethyl)-2-naphthalenamine bis-hydrochloride → 4-[(2-fluoro-benzenesulfonylamino)-methyl]-cyclohexanecarboxylic acid (6-methoxy-1-pyridin-3-ylmethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-amide

Guidance literature:

trans-4-[(2-fluorobenzenesulfonamido)methyl]cyclohexanecarboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

(cis)-1,2,3,4-tetrahydro-6-methoxy-1-(3-pyridinylmethyl)-2-naphthalenamine bis-hydrochloride; In N,N-dimethyl-formamide; Further stages.;

DOI:10.1021/jm990468g

upstream raw materials:

2-fluorobenzenesulfonyl chloride

trans-4-aminomethyl-cyclohexyl-carboxylic acid