Indiplon

Base Information

Chemical Name:Indiplon
CAS No.:325715-02-4
Molecular Formula:C20H16N4O2S
Molecular Weight:376.439
Hs Code.:
European Community (EC) Number:608-755-3
UNII:8BT63DA42E
DSSTox Substance ID:DTXSID80186270
Nikkaji Number:J1.855.248E
Wikipedia:Indiplon
Wikidata:Q6024927
NCI Thesaurus Code:C74385
Metabolomics Workbench ID:153552
ChEMBL ID:CHEMBL262075
Mol file:325715-02-4.mol

Synonyms:indiplon;NBI 34060

Suppliers and Price of Indiplon

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Indiplon
10mg
$ 403.00

TRC
Indiplon
2.5mg
$ 80.00

SynChem
INDIPLON 95%
10 mg
$ 70.00

DC Chemicals
Indiplon 99%
250 mg
$ 700.00

Crysdot
Indiplon 98+%
10mg
$ 68.00

Crysdot
Indiplon 98+%
50mg
$ 215.00

Chemenu
N-methyl-N-(3-(3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)acetamide 98%
50mg
$ 203.00

Cayman Chemical
Indiplon ≥95%
5mg
$ 58.00

Cayman Chemical
Indiplon ≥95%
10mg
$ 110.00

Cayman Chemical
Indiplon ≥95%
50mg
$ 435.00

Total 89 raw suppliers

Chemical Property of Indiplon

Chemical Property:

Refractive Index:1.699
PKA:-1.42±0.50(Predicted)
PSA：95.81000
Density:1.35 g/cm³
LogP:3.67150
Storage Temp.:Store at +4°C
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:376.09939694
Heavy Atom Count:27
Complexity:574

Purity/Quality:

99%, ^*data from raw suppliers

Indiplon ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4
Recent ClinicalTrials:An Exploratory Study of NBI-34060 Capsules and Next Day Functioning
Description Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner. Indiplon is selective for α1 subunits (EC50 = 2.6 nM) as compared with α2, α3, or α5 (EC50 = 24, 60, and 77 nM). Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.
Uses Indiplon is a member of pyrimidines with sedative, hypnotic. Indiplon has been used in trials studying the treatment of Insomnia and Depression.
Clinical Use Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. Like other non-benzodiazepine hypnotics, its mechanism of action is to modulate subunits, especially the alpha-1 subunit, of the GABA receptor complex in order to induce sedation. Indiplon was developed in two different formulations to address two different types of insomnia complaint: indiplon-IR (immediate release) was designed for sleep onset difficulties, while indiplon-MR (modified release) was developed for sleep maintenance insomnia.

Technology Process of Indiplon

There total 9 articles about Indiplon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 96219-87-3
(3-amino-1H-pyrazol-4-yl)(thien-2-yl)methanone

: N-[(3-dimethylaminoacryloyl)phenyl]-N-methylacetamide

: 325715-02-4
N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-a]-pyrimidin-7-yl}phenyl)acetamide

Guidance literature:: In acetic acid; for 3h; Heating / reflux;

Reference yield: 58.0%

: 88-15-3,97511-16-5
2-Acetylthiophene

: 96605-65-1
N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-methylacetamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 325715-02-4
N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-a]-pyrimidin-7-yl}phenyl)acetamide

Guidance literature:: 2-Acetylthiophene; N,N-dimethyl-formamide dimethyl acetal; With tris(N,N-dimethylbutyl)benzylammonium chloride; at 150 ℃; for 1h;

With hydroxylamine; at 150 ℃; for 5h;

N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-methylacetamide; Reagent/catalyst; Temperature; Further stages;