2',3',4',6'-TETRAMETHOXYACETOPHENONE

Base Information

• Chemical Name: 2',3',4',6'-TETRAMETHOXYACETOPHENONE
• CAS No.: 7508-05-6
• Molecular Formula: C12H16O5
• Molecular Weight: 240.256
• Mol file: 7508-05-6.mol

Synonyms:Acetophenone,2',3',4',6'-tetramethoxy- (7CI,8CI);1-(2,3,4,6-Tetramethoxyphenyl)ethanone;2',3',4',6'-Tetramethoxyacetophenone;NSC 401465;

Chemical Property of 2',3',4',6'-TETRAMETHOXYACETOPHENONE

Chemical Property:

• Vapor Pressure: 2.58E-05mmHg at 25°C
• Melting Point: 55–56°C
• Refractive Index: 1.492
• Boiling Point: 358.3 °C at 760 mmHg
• Flash Point: 158.1 °C
• PSA: 53.99000
• Density: 1.107g/cm³
• LogP: 1.92360

Purity/Quality:

98%min ^*data from raw suppliers

2',3',4',6'-TETRAMETHOXYACETOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',3',4',6'-TETRAMETHOXYACETOPHENONE

There total 16 articles about 2',3',4',6'-TETRAMETHOXYACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone (7507-98-4) + methyl iodide (74-88-4) → 1-(2,3,4,6-tetramethoxyphenyl)ethanone (7508-05-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c0cc04936k

Reference yield: 87.0%

1,2,3,5-tetramethoxybenzene (5333-45-9) + acetic anhydride (108-24-7) → 1-(2,3,4,6-tetramethoxyphenyl)ethanone (7508-05-6)

Guidance literature:

With In(OSO₂CF₃)3; at 85 - 95 ℃; for 0.05h; Irradiation; Microwave;

DOI:10.3987/COM-07-11054

Reference yield: 84.0%

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone (7507-98-4) + dimethyl sulfate (77-78-1) → 1-(2,3,4,6-tetramethoxyphenyl)ethanone (7508-05-6)

Guidance literature:

With potassium carbonate; In acetone; for 17h; Heating;

upstream raw materials:

1,2,3,5-tetramethoxybenzene

acetic acid

acetyl chloride

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone

Downstream raw materials:

1-phenyl-3-(2,3,4,6-tetramethoxy-phenyl)-propane-1,3-dione

2',3',4',6'-tetramethoxy-2-methoxymethoxy-trans-chalcone

1-(4-methoxy-phenyl)-3-(2,3,4,6-tetramethoxy-phenyl)-propane-1,3-dione

2-Acetyl-3-hydroxy-5-methoxy-[1,4]benzochinon

Refernces

• 1、 Tsukayama, Masao,Kusunoki, Eiji,Hossain, Mohammad M.,Kawamura, Yasuhiko,Hayashi, Shinji. "Miscrowave-assisted efficient synthesis of polymethoxyacetophenones and natural polymethoxyflavones, and thier inhibitory effects on melanogenesis". . p. 1589 - 1600. Retrieved 2008/09/17.
• 2、 Horie, Tokunaru,Tsukayama, Masao,Kawamura, Yasuhiko,Yamamoto, Shigeo. "STUDIES OF THE SELECTIVE O-ALKYLATION AND DEALKYLATION OF FLAVONOIDS. IX. A NEW METHOD FOR SYNTHESIZING 3,5-DIHYDROXY-7,8-DIMETHOXYFLAVONES FROM 3-HYDROXY-5,7,8-TRIMETHOXYFLAVONES". . p. 4465 - 4472. Retrieved 2007/10/02.