4-NITRO-PHENYL-N-BENZYLCARBAMATE

Base Information

• Chemical Name: 4-NITRO-PHENYL-N-BENZYLCARBAMATE
• CAS No.: 124068-97-9
• Molecular Formula: C14H12 N2 O4
• Molecular Weight: 272.26
• Hs Code.: 2924299090
• Mol file: 124068-97-9.mol

Synonyms:Carbamicacid, (phenylmethyl)-, 4-nitrophenyl ester (9CI); 4-Nitrophenyl(phenylmethyl)carbamate

Chemical Property of 4-NITRO-PHENYL-N-BENZYLCARBAMATE

Chemical Property:

• Vapor Pressure: 8.32E-08mmHg at 25°C
• Melting Point: 130.0 to 134.0 °C
• Boiling Point: 436.1°Cat760mmHg
• PKA: 10.54±0.46(Predicted)
• Flash Point: 217.5°C
• PSA: 84.15000
• Density: 1.306g/cm³
• LogP: 3.79750

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Nitrophenyl N-Benzylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Reactant for preparation of:Radiofluorinated quinoxalinedione derivatives as potential ligands of the AMPA receptorMono-substituted urea side chains in solid phase peptide synthesis4-substituted-1,2,4-triazolidine-3,5-dionesAryl carbamates as probes for the inhibition mechanism of cholesterol esterase

Technology Process of 4-NITRO-PHENYL-N-BENZYLCARBAMATE

There total 5 articles about 4-NITRO-PHENYL-N-BENZYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 4‐nitrophenyl N‐benzylcarbamate (124068-97-9)

Guidance literature:

With sodium hydrogencarbonate; In tert-butyl methyl ether; water; for 2h;

Reference yield: 95.0%

4-Nitrophenyl chloroformate (7693-46-1) + benzylamine (100-46-9) → 4‐nitrophenyl N‐benzylcarbamate (124068-97-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h;

DOI:10.1002/jlcr.1121

Reference yield: 92.0%

benzylamine hydrochloride (3287-99-8,39110-74-2,108321-65-9) + 4-Nitrophenyl chloroformate (7693-46-1) → 4‐nitrophenyl N‐benzylcarbamate (124068-97-9)

Guidance literature:

With sodium carbonate; In dichloromethane; for 168h;

DOI:10.1016/j.tetlet.2006.03.075

upstream raw materials:

4-chloromethoxycarbonyloxy-1-nitrobenzene

benzylamine

4-nitro-phenol

benzyl isothiocyanate

Downstream raw materials:

benzyl carbamic acid allyl ester

N-phenyl-N'-benzylurea

1-benzyl-3-(cyclohexylmethyl)urea

N-benzyl-N'-(3-hydroxy-propyl)-urea

Refernces

• 1、 Amoroso, R.,Di Stefano, A.,Lei, Hao,Mao, Shuai,Xin, Minghang,Yang, Xue-Yan,Yuan, Bo,Zhang, San-Qi,Zhao, Hong-Yi. "Synthesis and Biological Evaluation of 10-Substituted Camptothecin Derivatives with Improved Water Solubility and Activity". . p. 1000 - 1010. Retrieved 2021.
• 2、 Lin, Gialih,Lin, Wen-Yuan,Shieh, Chuen-Tzwu. "The enhancement of enantioselectivities for lipase-catalyzed reactions by using carbamates". . p. 8881 - 8884. Retrieved 1998.
• 3、 Peilleron, Laure,Retailleau, Pascal,Cariou, Kevin. "Synthesis of Cyclic N-Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)-Mediated Radical or Cationic Cyclizations of Unsaturated N-Alkoxyureas". supporting information. p. 5160 - 5169. Retrieved 2019/11/11.