(2-Chloroethyl)(3-(diethylmethylsilyl)propyl)dimethylammonium iodide

Base Information

• Chemical Name: (2-Chloroethyl)(3-(diethylmethylsilyl)propyl)dimethylammonium iodide
• CAS No.: 84584-76-9
• Molecular Formula: C₁₂H₂₉ClNSi*I
• Molecular Weight: 377.812
• DSSTox Substance ID: DTXSID301004872
• Mol file: 84584-76-9.mol

Synonyms:(2-Chloroethyl)(3-(diethylmethylsilyl)propyl)dimethylammonium iodide;Ammonium, (2-chloroethyl)(3-(diethylmethylsilyl)propyl)dimethyl-, iodide;1-Propanaminium, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N,N-dimethyl-, iodide;84584-76-9;C12H29ClNSi.I;C12-H29-Cl-N-Si.I;DTXSID301004872;LS-17166;N-(2-Chloroethyl)-3-[diethyl(methyl)silyl]-N,N-dimethylpropan-1-aminium iodide

Chemical Property of (2-Chloroethyl)(3-(diethylmethylsilyl)propyl)dimethylammonium iodide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 8
• Exact Mass: 377.08025
• Heavy Atom Count: 16
• Complexity: 167

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC[Si](C)(CC)CCC[N+](C)(C)CCCl.[I-]

Technology Process of (2-Chloroethyl)(3-(diethylmethylsilyl)propyl)dimethylammonium iodide

There total 3 articles about (2-Chloroethyl)(3-(diethylmethylsilyl)propyl)dimethylammonium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-chloro-propyl)-diethyl-methyl-silane (18279-97-5) → Methyldiethyl-<3-(N-methyl-N-2-chloroethylamino)propyl>silane methiodide (84584-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / Et₃N / butan-1-ol / 22 h / Heating

2: 13 percent / SOCl₂ / CHCl₃ / 4 h / 35 - 40 °C

3: 1.) aq. KOH / 1.) ether, 2.) ether, 35-40 deg C, 4 h; 20 deg C, 16 h

With potassium hydroxide; thionyl chloride; triethylamine; In chloroform; butan-1-ol;

DOI:10.1007/BF00772158

Reference yield:

2-{[3-(Diethyl-methyl-silanyl)-propyl]-methyl-amino}-ethanol (84584-58-7) → Methyldiethyl-<3-(N-methyl-N-2-chloroethylamino)propyl>silane methiodide (84584-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 13 percent / SOCl₂ / CHCl₃ / 4 h / 35 - 40 °C

2: 1.) aq. KOH / 1.) ether, 2.) ether, 35-40 deg C, 4 h; 20 deg C, 16 h

With potassium hydroxide; thionyl chloride; In chloroform;

DOI:10.1007/BF00772158

Reference yield:

(2-Chloro-ethyl)-[3-(diethyl-methyl-silanyl)-propyl]-methyl-amine; hydrochloride (84584-73-6) + methyl iodide (74-88-4) → Methyldiethyl-<3-(N-methyl-N-2-chloroethylamino)propyl>silane methiodide (84584-76-9)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) ether, 2.) ether, 35-40 deg C, 4 h; 20 deg C, 16 h;

DOI:10.1007/BF00772158

upstream raw materials:

(2-Chloro-ethyl)-[3-(diethyl-methyl-silanyl)-propyl]-methyl-amine; hydrochloride

methyl iodide

(3-chloro-propyl)-diethyl-methyl-silane

2-{[3-(Diethyl-methyl-silanyl)-propyl]-methyl-amino}-ethanol