1,2,5,6-Tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride

Base Information

• Chemical Name: 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride
• CAS No.: 139886-03-6
• Molecular Formula: C₇H₁₂N₂O*ClH
• Molecular Weight: 176.646
• Mol file: 139886-03-6.mol

Synonyms:1-alkyl-1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride;RU 35963;RU-35963

Chemical Property of 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride

Chemical Property:

• Vapor Pressure: 0.114mmHg at 25°C
• Boiling Point: 220.3°Cat760mmHg
• Flash Point: 87.1°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 176.0716407
• Heavy Atom Count: 11
• Complexity: 152

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CON=CC1=CCCNC1.Cl
• Isomeric SMILES: CO/N=C/C1=CCCNC1.Cl

Technology Process of 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride

There total 7 articles about 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-methoxylamine hydrochloride (593-56-6) + 1,2,5,6-tetrahydropyridine-3-carboxaldehyde hydrochloride (114485-48-2) → RU 35963 (139886-03-6)

Guidance literature:

In water; for 1h; Ambient temperature;

DOI:10.1016/0223-5234(91)90128-A

Reference yield:

3-Pyridinecarbaldehyde oxime O-methyl ether (57980-43-5,283151-51-9) → RU 35963 (139886-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / ethanol / 10 h / Heating

2: 69 percent / NaBH₄ / methanol / 1 h / Ambient temperature

3: 1,2-dichloro-ethane / 2 h / Heating

4: methanol / 0.5 h / Heating

With sodium tetrahydroborate; In methanol; ethanol; 1,2-dichloro-ethane;

DOI:10.1016/0223-5234(91)90128-A

Reference yield:

3-methoxyiminomethyl-1-ethylpyridinium iodide (114485-53-9) → RU 35963 (139886-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / NaBH₄ / methanol / 1 h / Ambient temperature

2: 1,2-dichloro-ethane / 2 h / Heating

3: methanol / 0.5 h / Heating

With sodium tetrahydroborate; In methanol; 1,2-dichloro-ethane;

DOI:10.1016/0223-5234(91)90128-A

upstream raw materials:

N-methoxylamine hydrochloride

1,2,5,6-tetrahydropyridine-3-carboxaldehyde hydrochloride

5-(Methoxyimino-methyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 1-chloro-ethyl ester

3-Pyridinecarbaldehyde oxime O-methyl ether

Downstream raw materials:

milameline

1-Benzyl-1,2,5,6-tetrahydro-pyridine-3-carbaldehyde O-methyl-oxime

Refernces