8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde

Base Information

• Chemical Name: 8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde
• CAS No.: 68304-21-2
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.1675
• Mol file: 68304-21-2.mol

Synonyms:5-Quinolinecarboxaldehyde,1,2-dihydro-8-hydroxy-2-oxo;8-hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde;8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde;5-Formyl-8-hydroxycarbostyril;5-formyl-8-hydroxycarbostyryl;

Chemical Property of 8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde

Chemical Property:

• Vapor Pressure: 3.65E-09mmHg at 25°C
• Melting Point: 315-317 °C (decomp)
• Boiling Point: 462.2°Cat760mmHg
• PKA: 6.65±0.20(Predicted)
• Flash Point: 233.3°C
• PSA: 70.16000
• Density: 1.431g/cm³
• LogP: 1.04620
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO, Methanol (Sparingly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Formyl-8-hydroxycarbostyril ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Formyl-8-hydroxycarbostyril is a metabolite of procaterol hydrochloride (Meptin), a β2-adrenergic agonist used in the treatment of asthma.

Technology Process of 8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde

There total 6 articles about 8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

8-(benzyloxy)carbostyril-5-carboxaldehyde (66546-38-1) → 8-hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde (68304-21-2)

Guidance literature:

8-(benzyloxy)carbostyril-5-carboxaldehyde; In dichloromethane; at -5 - 0 ℃;

With boron trichloride; In dichloromethane; at -5 - 0 ℃; for 2h;

Reference yield: 72.0%

C11H11NO4 → 8-hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde (68304-21-2)

Guidance literature:

With sodium periodate; In methanol; water; at 20 ℃; for 0.5h;

Reference yield:

procaterol hydrochloride → 8-hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde (68304-21-2) + 8-Hydroxy-1H-quinolin-2-one (15450-76-7)

Guidance literature:

With pH 6.0; at 80 ℃; Thermodynamic data; Rate constant; Kinetics; degradation in acid solution, pH and heavy metal ions presence, E_a;

DOI:10.1002/jps.2600760907

upstream raw materials:

8-(benzyloxy)carbostyril-5-carboxaldehyde

(R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone

Refernces

• 1、 -. "Method for preparing 5-formyl-8-hydroxy-1, 3, 4-trihydroquinoline-2-ketone". . . Retrieved 2021/08/07.