1,3-Diazaadamantane

Base Information

• Chemical Name: 1,3-Diazaadamantane
• CAS No.: 281-29-8
• Molecular Formula: C₈H₁₄N₂
• Molecular Weight: 138.213
• Hs Code.: 2933990090
• Mol file: 281-29-8.mol

Synonyms:1,3-Diazaadamantane(8CI)

Chemical Property of 1,3-Diazaadamantane

Chemical Property:

• Vapor Pressure: 0.517mmHg at 25°C
• Boiling Point: 191.3°Cat760mmHg
• Flash Point: 64°C
• PSA: 6.48000
• Density: 1.16g/cm³
• LogP: 0.08700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Diazaadamantane

There total 12 articles about 1,3-Diazaadamantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,3-diazaadamantane monohydrochloride (1402430-52-7) → 1,3-diaza-adamantane (281-29-8)

Guidance literature:

With potassium carbonate; In water; for 0.5h;

DOI:10.1002/poc.2909

Reference yield: 89.0%

5,7-dibromo-1,3-diazaadamantane → 1,3-diaza-adamantane (281-29-8)

Guidance literature:

With sodium hydroxide; nickel; hydrazine hydrate; In ethanol; for 3.5h;

DOI:10.1007/BF00531665

Reference yield: 25.0%

3,7-diazabicyclo{3.3.1}nonane (280-74-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(isocyanomethyl)-4-methoxybenzene (1197-58-6) + benzoic acid (65-85-0,8013-63-6) → 1,3-diaza-adamantane (281-29-8) + 2-(7-benzoyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)-N-(4-methoxybenzyl)acetamide

Guidance literature:

3,7-diazabicyclo{3.3.1}nonane; formaldehyd; benzoic acid; In methanol; for 2h; Inert atmosphere; Reflux;

1-(isocyanomethyl)-4-methoxybenzene; In methanol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/hlca.201500505

upstream raw materials:

3,7-diazabicyclo{3.3.1}nonane

formaldehyd

diiodomethane

5,7-dinitro-1,3-diazaadamantane

Refernces

• 1、 Kuznetsov, A. I.,Romanova, K. I.,Basargin, E. B.,Moskovkin, A. S.. "HETEROADAMANTANES AND THEIR DERIVATIVES. 19. SYNTHESES OF 1,3-DIAZAADAMANTANE AND 6,6-DIMETHYL-1,3-DIAZAADAMANTANE BASED ON THE CORRESPONDING 5,7-DINITRO DERIVATIVES". . p. 200 - 203. Retrieved 1993.