dimethyl 2-benzyl-1H-pyrrole-3,4-dicarboxylate

Base Information

• Chemical Name: dimethyl 2-benzyl-1H-pyrrole-3,4-dicarboxylate
• CAS No.: 106762-00-9
• Molecular Formula: C15H15 N O4
• Molecular Weight: 273.2839
• Mol file: 106762-00-9.mol

Synonyms:1H-Pyrrole-3,4-dicarboxylicacid, 2-(phenylmethyl)-, dimethyl ester (9CI)

Chemical Property of dimethyl 2-benzyl-1H-pyrrole-3,4-dicarboxylate

Chemical Property:

• Vapor Pressure: 3.53E-09mmHg at 25°C
• Boiling Point: 474.7°Cat760mmHg
• Flash Point: 240.9°C
• Density: 1.225g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dimethyl 2-benzyl-1H-pyrrole-3,4-dicarboxylate

There total 5 articles about dimethyl 2-benzyl-1H-pyrrole-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

DL-phenylalanine methyl ester (15028-44-1) + 2-(dimethylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde (111680-71-8) + propynoic acid methyl ester (922-67-8) → C25H26N4O5 + 2-(dimethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one (84292-17-1) + 2-benzyl-3,4-dicarbomethoxypyrrole (106762-00-9)

Guidance literature:

DL-phenylalanine methyl ester; 2-(dimethylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde; In toluene; at 85 ℃; for 1h;

propynoic acid methyl ester; In toluene; at 15 ℃; for 72h; Further stages.;

DOI:10.1016/j.tetlet.2006.12.018

Reference yield: 78.0%

C25H26N4O5 → 2-(dimethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one (84292-17-1) + 2-benzyl-3,4-dicarbomethoxypyrrole (106762-00-9)

Guidance literature:

In toluene; at 85 ℃; for 12h;

DOI:10.1016/j.tetlet.2006.12.018

Reference yield: 37.0%

N-<2-phenyl-1-(phenylthio)ethylidene>-1-(trimethylsilyl)methylamine (106761-99-3) + dimethyl acetylenedicarboxylate (762-42-5) → 2-benzyl-3,4-dicarbomethoxypyrrole (106762-00-9)

Guidance literature:

With silver fluoride; In acetonitrile; for 16h; Ambient temperature;

DOI:10.1021/jo00382a011

upstream raw materials:

N-<2-phenyl-1-(phenylthio)ethylidene>-1-(trimethylsilyl)methylamine

dimethyl acetylenedicarboxylate

DL-phenylalanine methyl ester

2-(dimethylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde